Nutrient depletion·Biotin (Vitamin B7)·Reviewed June 9, 2026
What depletes biotin?
3 medications in the NutriStack database are documented to lower Biotin with ongoing use. Depletion builds slowly and is easy to miss; the table below shows how each medication drives it and which biomarker to check. Never start a replacement supplement without your prescriber's input.
Biotin (Vitamin B7) depletion at a glance.
A quick, data-grounded summary. The per-medication table is below.
3 medications in the NutriStack database are documented to lower Biotin with ongoing use. Depletion builds slowly and is easy to miss; the table below shows how each medication drives it and which biomarker to check. Never start a replacement supplement without your prescriber's input.
What is documented to lower biotin.
Worst documented severity first. Open any medication for its full interaction and depletion guide. Absence from this table means no documented record, not proven safety.
| Medication | Severity | How it lowers biotin | Monitor |
|---|---|---|---|
| Carbamazepine Antiepileptic | Moderate | Chronic carbamazepine use has been associated with lower biotin status. | Clinical assessment |
| Phenytoin Antiepileptic | Moderate | Chronic anticonvulsant therapy can lower biotin status through increased metabolic turnover. | Clinical assessment |
| Valproic Acid Mood Stabilizer / Anticonvulsant | Mild | Valproate therapy may lower biotin status in susceptible users. | Clinical assessment |
If you need to restore biotin.
Repletion is not automatic: dose, form, and timing depend on the medication involved, and some pairings need separation from the very drug causing the depletion. Confirm with your prescriber before adding biotin.
Common biotin depletion questions.
Quick answers drawn from the table above.
Which medications deplete biotin?
3 medications in the NutriStack database are documented to lower biotin, including Carbamazepine, Phenytoin, and Valproic Acid. Severity differs by drug; the full table with mechanisms and monitoring biomarkers is on this page.
How do I know if my biotin is low?
The biomarkers used to track biotin status in this context include Clinical assessment. If you take one of the medications above long term, ask your prescriber whether checking is worthwhile; depletion develops gradually.
Should I take a biotin supplement with these medications?
Not automatically. Documented depletion makes repletion worth discussing, but the right answer depends on your labs, dose, and the specific drug. Bring it up with your prescriber or pharmacist.
Check your whole stack
See what your medications deplete.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.