Nutrient depletion·CoQ10·Reviewed June 9, 2026
What depletes coq10?
16 medications in the NutriStack database are documented to lower CoQ10 with ongoing use. The pattern spans 10 drug classes. Depletion builds slowly and is easy to miss; the table below shows how each medication drives it and which biomarker to check. Never start a replacement supplement without your prescriber's input.
CoQ10 depletion at a glance.
A quick, data-grounded summary. The per-medication table is below.
16 medications in the NutriStack database are documented to lower CoQ10 with ongoing use. The pattern spans 10 drug classes. Depletion builds slowly and is easy to miss; the table below shows how each medication drives it and which biomarker to check. Never start a replacement supplement without your prescriber's input.
What is documented to lower coq10.
Worst documented severity first. Open any medication for its full interaction and depletion guide. Absence from this table means no documented record, not proven safety.
| Medication | Severity | How it lowers coq10 | Monitor |
|---|---|---|---|
| Atorvastatin HMG-CoA Reductase Inhibitor (Statin) | Moderate | HMG-CoA reductase inhibition reduces mevalonate pathway flux, lowering endogenous CoQ10 synthesis alongside cholesterol synthesis. | Plasma CoQ10 |
| Lovastatin HMG-CoA Reductase Inhibitor (Statin) | Moderate | HMG-CoA reductase inhibition reduces mevalonate pathway flux, lowering endogenous CoQ10 synthesis alongside cholesterol synthesis. | Plasma CoQ10 |
| Pravastatin HMG-CoA Reductase Inhibitor (Statin) | Moderate | HMG-CoA reductase inhibition reduces mevalonate pathway flux, lowering endogenous CoQ10 synthesis alongside cholesterol synthesis. | Plasma CoQ10 |
| Rosuvastatin HMG-CoA Reductase Inhibitor (Statin) | Moderate | HMG-CoA reductase inhibition reduces mevalonate pathway flux, lowering endogenous CoQ10 synthesis alongside cholesterol synthesis. | Plasma CoQ10 |
| Simvastatin HMG-CoA Reductase Inhibitor (Statin) | Moderate | HMG-CoA reductase inhibition reduces mevalonate pathway flux, lowering endogenous CoQ10 synthesis alongside cholesterol synthesis. | Plasma CoQ10 |
| Atenolol Beta-1 Selective Adrenergic Blocker | Mild | Chronic beta-blocker therapy has been associated with lower tissue CoQ10 status and reduced mitochondrial electron transport support. | Plasma CoQ10 |
| Bisoprolol Beta-1 Selective Adrenergic Blocker | Mild | Chronic beta-blocker therapy has been associated with lower tissue CoQ10 status and reduced mitochondrial electron transport support. | Plasma CoQ10 |
| Carvedilol Non-Selective Beta-Blocker with Alpha-1 Blockade | Mild | Chronic beta-blocker therapy has been associated with lower tissue CoQ10 status and reduced mitochondrial electron transport support. | Plasma CoQ10 |
| Chlorthalidone Thiazide-Like Diuretic | Mild | Beta-blocker and diuretic therapy are associated with lower CoQ10 status in some long-term users, likely through increased oxidative demand and... | Plasma CoQ10 |
| Fenofibrate Fibrate (PPAR-alpha agonist) | Mild | Fibrates inhibit HMG-CoA reductase activity indirectly and reduce mevalonate pathway flux similar to (though more weakly than) statins, lowering... | Plasma/serum CoQ10 (rarely measured clinically); monitor for myalgia and serum creatine kinase if myopathy suspected |
| Gemfibrozil Fibrate (fibric acid derivative) | Mild | Fibrates lower circulating cholesterol and lipoproteins, which serve as the principal transport vehicles for the lipophilic,... | Plasma coenzyme Q10 level (interpret relative to total cholesterol/LDL, as CoQ10 tracks with lipoprotein concentration); creatine kinase if myopathy is suspected |
| Hydrochlorothiazide Thiazide Diuretic | Mild | Beta-blocker and diuretic therapy are associated with lower CoQ10 status in some long-term users, likely through increased oxidative demand and... | Plasma CoQ10 |
| Labetalol Combined alpha/beta-adrenergic blocker | Mild | Like other beta-adrenergic blocking agents, labetalol can inhibit Coenzyme Q10 (ubiquinone)-dependent enzymes and reduce CoQ10-related mitochondrial... | Plasma Coenzyme Q10 concentration (not routinely measured clinically) |
| Metoprolol Beta-1 Selective Adrenergic Blocker | Mild | Chronic beta-blocker therapy has been associated with lower tissue CoQ10 status and reduced mitochondrial electron transport support. | Plasma CoQ10 |
| Nebivolol Beta-blocker (beta-1 selective with vasodilation) | Mild | Beta-adrenergic blockers, including nebivolol, are recognized as a class to lower circulating coenzyme Q10 (ubiquinone). The proposed mechanism is... | Plasma/serum coenzyme Q10 concentration (not routinely measured clinically) |
| Propranolol Non-Selective Beta-Adrenergic Blocker | Mild | Chronic beta-blocker therapy has been associated with lower tissue CoQ10 status and reduced mitochondrial electron transport support. | Plasma CoQ10 |
If you need to restore coq10.
Repletion is not automatic: dose, form, and timing depend on the medication involved, and some pairings need separation from the very drug causing the depletion. Confirm with your prescriber before adding coq10.
Common coq10 depletion questions.
Quick answers drawn from the table above.
Which medications deplete coq10?
16 medications in the NutriStack database are documented to lower coq10, including Atorvastatin, Lovastatin, Pravastatin, Rosuvastatin, and Simvastatin. Severity differs by drug; the full table with mechanisms and monitoring biomarkers is on this page.
How do I know if my coq10 is low?
The biomarkers used to track coq10 status in this context include Plasma CoQ10, Plasma/serum CoQ10 (rarely measured clinically); monitor for myalgia and serum creatine kinase if myopathy suspected, and Plasma coenzyme Q10 level (interpret relative to total cholesterol/LDL, as CoQ10 tracks with lipoprotein concentration); creatine kinase if myopathy is suspected. If you take one of the medications above long term, ask your prescriber whether checking is worthwhile; depletion develops gradually.
Should I take a coq10 supplement with these medications?
Not automatically. Documented depletion makes repletion worth discussing, but the right answer depends on your labs, dose, and the specific drug. Bring it up with your prescriber or pharmacist.
Check your whole stack
See what your medications deplete.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.