Nutrient depletion·Sodium·Reviewed June 9, 2026
What depletes sodium?
19 medications in the NutriStack database are documented to lower Sodium with ongoing use, most notably Citalopram, Escitalopram, Fluoxetine, and Fluvoxamine. The pattern spans 11 drug classes. Depletion builds slowly and is easy to miss; the table below shows how each medication drives it and which biomarker to check. Never start a replacement supplement without your prescriber's input.
Sodium depletion at a glance.
A quick, data-grounded summary. The per-medication table is below.
19 medications in the NutriStack database are documented to lower Sodium with ongoing use, most notably Citalopram, Escitalopram, Fluoxetine, and Fluvoxamine. The pattern spans 11 drug classes. Depletion builds slowly and is easy to miss; the table below shows how each medication drives it and which biomarker to check. Never start a replacement supplement without your prescriber's input.
What is documented to lower sodium.
Worst documented severity first. Open any medication for its full interaction and depletion guide. Absence from this table means no documented record, not proven safety.
| Medication | Severity | How it lowers sodium | Monitor |
|---|---|---|---|
| Citalopram SSRI | Significant | SSRI-induced SIADH can lower serum sodium, especially in older adults and during the first weeks of therapy. | Serum sodium |
| Escitalopram SSRI | Significant | SSRI-induced SIADH can lower serum sodium, especially in older adults and during the first weeks of therapy. | Serum sodium |
| Fluoxetine SSRI | Significant | SSRI-induced SIADH can lower serum sodium, especially in older adults and during the first weeks of therapy. | Serum sodium |
| Fluvoxamine SSRI | Significant | SSRI-induced SIADH can lower serum sodium, especially in older adults and during the first weeks of therapy. | Serum sodium |
| Oxcarbazepine Anticonvulsant sodium-channel modulator | Significant | Oxcarbazepine can cause dilutional hyponatremia through antidiuretic hormone-like effects and impaired free-water handling, lowering serum sodium... | Serum sodium |
| Paroxetine SSRI | Significant | SSRI-induced SIADH can lower serum sodium, especially in older adults and during the first weeks of therapy. | Serum sodium |
| Sertraline SSRI | Significant | SSRI-induced SIADH can lower serum sodium, especially in older adults and during the first weeks of therapy. | Serum sodium |
| Amitriptyline Tricyclic Antidepressant (TCA) | Moderate | Antidepressant-associated SIADH can increase renal free-water retention and dilute serum sodium, producing hyponatremia. | Serum sodium |
| Chlorthalidone Thiazide-Like Diuretic | Moderate | Thiazides are a common medication cause of hyponatremia, especially in older adults. | Serum sodium |
| Desvenlafaxine SNRI | Moderate | Antidepressant-associated SIADH can increase renal free-water retention and dilute serum sodium, producing hyponatremia. | Serum sodium |
| Duloxetine SNRI | Moderate | Antidepressant-associated SIADH can increase renal free-water retention and dilute serum sodium, producing hyponatremia. | Serum sodium |
| Furosemide Loop Diuretic | Moderate | Potent natriuresis can produce hyponatremia, especially with higher doses or high free-water intake. | Serum sodium |
| Hydrochlorothiazide Thiazide Diuretic | Moderate | Thiazides are a common medication cause of hyponatremia, especially in older adults. | Serum sodium |
| Mirtazapine Atypical Antidepressant (NaSSA) | Moderate | Antidepressant-associated SIADH can increase renal free-water retention and dilute serum sodium, producing hyponatremia. | Serum sodium |
| Nortriptyline Tricyclic Antidepressant (TCA) | Moderate | Antidepressant-associated SIADH can increase renal free-water retention and dilute serum sodium, producing hyponatremia. | Serum sodium |
| Trazodone Atypical Antidepressant (SARI) | Moderate | Antidepressant-associated SIADH can increase renal free-water retention and dilute serum sodium, producing hyponatremia. | Serum sodium |
| Venlafaxine SNRI | Moderate | Antidepressant-associated SIADH can increase renal free-water retention and dilute serum sodium, producing hyponatremia. | Serum sodium |
| Losartan/Hydrochlorothiazide Angiotensin II receptor blocker plus thiazide diuretic (fixed-dose combination) | Mild | As a natriuretic agent, hydrochlorothiazide directly increases renal sodium excretion; combined with reduced thirst or low sodium intake in older... | Serum sodium |
| Perindopril ACE Inhibitor | Mild | ACE inhibitors reduce angiotensin II and aldosterone, decreasing renal sodium reabsorption and promoting natriuresis, which can lower serum sodium... | Serum sodium |
If you need to restore sodium.
Sodium is usually managed through diet and clinical care rather than supplementation; talk to your prescriber about monitoring.
Common sodium depletion questions.
Quick answers drawn from the table above.
Which medications deplete sodium?
19 medications in the NutriStack database are documented to lower sodium, including Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, and Oxcarbazepine. Severity differs by drug; the full table with mechanisms and monitoring biomarkers is on this page.
How do I know if my sodium is low?
The biomarkers used to track sodium status in this context include Serum sodium. If you take one of the medications above long term, ask your prescriber whether checking is worthwhile; depletion develops gradually.
Should I take a sodium supplement with these medications?
Not automatically. Documented depletion makes repletion worth discussing, but the right answer depends on your labs, dose, and the specific drug. Bring it up with your prescriber or pharmacist.
Check your whole stack
See what your medications deplete.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.