Nutrient depletion·Vitamin E·Reviewed June 9, 2026
What depletes vitamin e?
3 medications in the NutriStack database are documented to lower Vitamin E with ongoing use. The pattern spans 3 drug classes. Depletion builds slowly and is easy to miss; the table below shows how each medication drives it and which biomarker to check. Never start a replacement supplement without your prescriber's input.
Vitamin E depletion at a glance.
A quick, data-grounded summary. The per-medication table is below.
3 medications in the NutriStack database are documented to lower Vitamin E with ongoing use. The pattern spans 3 drug classes. Depletion builds slowly and is easy to miss; the table below shows how each medication drives it and which biomarker to check. Never start a replacement supplement without your prescriber's input.
What is documented to lower vitamin e.
Worst documented severity first. Open any medication for its full interaction and depletion guide. Absence from this table means no documented record, not proven safety.
| Medication | Severity | How it lowers vitamin e | Monitor |
|---|---|---|---|
| Cholestyramine Bile acid sequestrant | Moderate | Bile acid sequestration can impair absorption of fat-soluble vitamin E during long-term use. | Alpha-tocopherol if deficiency suspected |
| Ezetimibe Cholesterol absorption inhibitor | Mild | Ezetimibe inhibits the intestinal sterol transporter NPC1L1 at the brush border of enterocytes, reducing absorption of dietary and biliary... | Serum alpha-tocopherol, ideally expressed per mmol of total cholesterol plus triglycerides (lipid-standardized) |
| Fenofibrate Fibrate (PPAR-alpha agonist) | Mild | Fenofibrate lowers circulating lipoproteins (VLDL and LDL) that transport fat-soluble vitamin E (tocopherols) in plasma. Because measured serum... | Serum alpha-tocopherol, ideally interpreted relative to serum lipids (tocopherol-to-cholesterol ratio) |
If you need to restore vitamin e.
Repletion is not automatic: dose, form, and timing depend on the medication involved, and some pairings need separation from the very drug causing the depletion. Confirm with your prescriber before adding vitamin e.
Common vitamin e depletion questions.
Quick answers drawn from the table above.
Which medications deplete vitamin e?
3 medications in the NutriStack database are documented to lower vitamin e, including Cholestyramine, Ezetimibe, and Fenofibrate. Severity differs by drug; the full table with mechanisms and monitoring biomarkers is on this page.
How do I know if my vitamin e is low?
The biomarkers used to track vitamin e status in this context include Alpha-tocopherol if deficiency suspected, Serum alpha-tocopherol, ideally expressed per mmol of total cholesterol plus triglycerides (lipid-standardized), and Serum alpha-tocopherol, ideally interpreted relative to serum lipids (tocopherol-to-cholesterol ratio). If you take one of the medications above long term, ask your prescriber whether checking is worthwhile; depletion develops gradually.
Should I take a vitamin e supplement with these medications?
Not automatically. Documented depletion makes repletion worth discussing, but the right answer depends on your labs, dose, and the specific drug. Bring it up with your prescriber or pharmacist.
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See what your medications deplete.
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