Drug class·Beta-Blockers·Reviewed June 9, 2026
Beta-blockers and supplements: watch the additive effects.
Beta-blockers interact with supplements mostly through addition: anything that further lowers heart rate or blood pressure, or that opposes the drug with stimulant load, changes how the medication feels. The documented pairings for each beta-blocker are below.
Beta-Blockers at a glance.
A quick, data-grounded summary. The per-drug tables are below.
Across the 8 beta-blockers in the NutriStack database (Metoprolol, Atenolol, Carvedilol, Nebivolol, and Propranolol and 3 more), 19 substances have a documented interaction. Long-term use of some medications in this class is also associated with lower CoQ10 and Coenzyme Q10; the depletion table shows exactly which drugs. Interactions are documented per drug, and members of a class do not all behave the same, so check your exact medication below. None of this replaces your prescriber's advice.
The beta-blockers we track.
Open any medication for its own full interaction and depletion guide.
Substances that interact with beta-blockers.
Merged across the class, highest severity first. The 'Documented for' column shows which members carry the interaction record; an absent drug means no documented record, not proven safety.
| Substance | Interaction | Documented for | What happens |
|---|---|---|---|
| Coenzyme Q10 | Caution | Metoprolol, Atenolol, Carvedilol +3 more | Metoprolol: Beta-blockers including metoprolol may reduce endogenous CoQ10 levels by inhibiting CoQ10-dependent mitochondrial enzymes. Some studies... |
| Garlic Extract | Caution | Metoprolol, Atenolol, Nebivolol +1 more | Metoprolol: Aged garlic extract lowers systolic blood pressure by roughly 8 mmHg in hypertensive patients, comparable to first-line antihypertensives.... |
| Magnesium Glycinate | Caution | Metoprolol, Nebivolol, Labetalol +1 more | Nebivolol: Magnesium Glycinate may add to the blood-pressure-lowering effect of Nebivolol. |
| L-Citrulline | Caution | Metoprolol, Nebivolol, Labetalol | Metoprolol: L-Citrulline is converted to L-arginine and raises plasma arginine more efficiently than arginine itself, producing nitric-oxide-mediated... |
| Taurine | Caution | Metoprolol, Atenolol, Carvedilol | Metoprolol: Taurine modestly lowers both systolic and diastolic blood pressure (~3 mmHg each in meta-analysis) and has direct heart-rate-lowering... |
| Berberine | Caution | Nebivolol, Labetalol | Nebivolol: Berberine may lower glucose, while beta blockers can mask adrenergic warning signs of hypoglycemia such as tachycardia. |
| L-Arginine | Caution | Metoprolol, Atenolol | Metoprolol: L-Arginine is a nitric oxide precursor that lowers blood pressure on its own. Stacked with metoprolol's beta1 blockade, the combined fall... |
| L-Theanine | Caution | Metoprolol, Propranolol | Metoprolol: L-Theanine blunts stress-induced rises in blood pressure and heart rate in high-stress-responder subjects. Combined with metoprolol, the... |
| Potassium | Caution | Metoprolol, Sotalol | Metoprolol: Metoprolol alone does not significantly affect potassium levels. However, it is frequently prescribed alongside diuretics (e.g.,... |
| Ashwagandha | Caution | Propranolol | Ashwagandha lowers cortisol and dampens sympathetic activity, which can modestly reduce heart rate and blood pressure. Combined with... |
| Fish Oil Triple Strength | Caution | Atenolol | Concentrated fish oil products deliver 2-3 g of EPA/DHA per softgel, which produces meaningful blood-pressure reductions on top of... |
| Green Tea Extract | Caution | Propranolol | Green tea extract contains caffeine, which propranolol blunts the cardiovascular response to, and vice versa. High-dose green tea extract... |
| St. John's Wort | Caution | Nebivolol | St. John's Wort is a broad inducer of drug-metabolizing enzymes. While nebivolol is primarily a CYP2D6 substrate, St. John's Wort can... |
| Melatonin | Synergy | Metoprolol, Atenolol, Carvedilol +2 more | Metoprolol: Metoprolol suppresses endogenous melatonin production by approximately 50% through blockade of beta-1 adrenergic receptors on the pineal... |
| Fish Oil | Synergy | Metoprolol, Atenolol, Carvedilol | Metoprolol: Omega-3 fatty acids in fish oil produce small but consistent reductions in blood pressure (~2-3 mmHg systolic at doses of 2-3 g/day) and... |
| Acetyl-L-Carnitine | Synergy | Metoprolol, Carvedilol | Metoprolol: Acetyl-L-carnitine supports cardiac mitochondrial function and modestly lowers diastolic blood pressure. Combined with metoprolol in heart... |
| L-Carnitine | Synergy | Metoprolol, Carvedilol | Metoprolol: L-Carnitine modestly lowers diastolic blood pressure and supports cardiac fatty-acid oxidation. Adjunctive use with metoprolol in heart... |
| Coenzyme Q10 Ubiquinol | Synergy | Metoprolol | Beta-blockers including metoprolol inhibit CoQ10-dependent mitochondrial enzymes, reducing endogenous CoQ10 levels. Metoprolol inhibits... |
| Resveratrol | Synergy | Metoprolol | High-dose resveratrol (≥150 mg/day) modestly reduces systolic blood pressure and improves endothelial function. Combined with metoprolol,... |
What beta-blockers can deplete.
Nutrients associated with long-term use somewhere in this class, worst documented severity first. Discuss any replacement with your prescriber.
| Nutrient | Severity | Documented for | Replace with | Monitor |
|---|---|---|---|---|
| CoQ10 | Mild | Metoprolol, Atenolol, Carvedilol +2 more | Coenzyme Q10 | Plasma CoQ10 |
| Coenzyme Q10 | Mild | Nebivolol, Labetalol | Coenzyme Q10 (ubiquinone or ubiquinol) | Plasma/serum coenzyme Q10 concentration (not routinely measured clinically) |
Common beta-blockers questions.
Quick answers drawn from the tables above.
Do all beta-blockers interact with supplements the same way?
No. Interactions are documented per drug, and the 8 beta-blockers in the database differ in how they are absorbed and cleared. The class table above shows which members carry each record; a drug without a record is undocumented, not proven safe.
Do beta-blockers deplete any nutrients?
Some medications in this class are documented to lower CoQ10 and Coenzyme Q10 with long-term use; the depletion table on this page shows which specific drugs carry each record. Useful biomarkers to monitor include Plasma CoQ10 and Plasma/serum coenzyme Q10 concentration (not routinely measured clinically). Ask your prescriber before adding a replacement supplement.
Is it safe to take Coenzyme Q10 with beta-blockers?
NutriStack classifies the Coenzyme Q10 and Metoprolol pairing as caution: Beta-blockers including metoprolol may reduce endogenous CoQ10 levels by inhibiting CoQ10-dependent mitochondrial enzymes. Some studies suggest CoQ10 supplementation... The interaction is documented for 6 of the 8 beta-blockers, and severity differs by drug. Always confirm with your prescriber.
Check your whole stack
See how your medication fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.