Medication·Interactions·Reviewed June 9, 2026
Acitretin interactions.
Acitretin has 4 documented interactions in the NutriStack database, including 2 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Acitretin at a glance.
A quick, data-grounded summary. The full tables are below.
Acitretin has 4 documented interactions in the NutriStack database, including 2 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with acitretin.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Alcohol | Contraindicated | Alcohol can convert acitretin back into etretinate, a much more lipophilic retinoid with a very long elimination time. This is especially dangerous... details → |
| Vitamin A | Contraindicated | Acitretin is a systemic retinoid with vitamin A-like toxicity. Adding preformed vitamin A supplements can stack retinoid effects and increase the... details → |
| Fish Oil | Synergy | Acitretin can raise triglycerides, and fish oil may help reduce retinoid-associated hypertriglyceridemia. Direct evidence is strongest for... |
| Fish Oil Triple Strength | Synergy | Concentrated fish oil may help manage triglyceride elevations during acitretin therapy. Evidence comes from systemic retinoid studies and acitretin... |
The full acitretin profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common acitretin questions.
Quick answers drawn from the tables above.
What interacts with Acitretin?
In the NutriStack database, Acitretin has 4 documented interactions. The most notable include Alcohol, Vitamin A, Fish Oil, and Fish Oil Triple Strength. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Acitretin?
Acitretin is flagged against 2 substances in the database, including Alcohol and Vitamin A. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take Alcohol with Acitretin?
NutriStack classifies the Alcohol and Acitretin pairing as contraindicated: Alcohol can convert acitretin back into etretinate, a much more lipophilic retinoid with a very long elimination time. This is especially dangerous for anyone who could... Do not drink alcohol while taking acitretin. If pregnancy is possible, avoid alcohol during treatment and for at least 2 months after stopping... Always confirm with your prescriber.
Check your whole stack
See how acitretin fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.