Medication·Interactions·Reviewed June 9, 2026
Acyclovir interactions.
Acyclovir has 5 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Acyclovir at a glance.
A quick, data-grounded summary. The full tables are below.
Acyclovir has 5 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with acyclovir.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| L-Lysine | Synergy | L-lysine is used by some patients as adjunctive prophylaxis against herpes simplex recurrences, working by a different mechanism than acyclovir.... |
| Quercetin | Synergy | Quercetin has demonstrated antiviral activity against HSV-1 in vitro and in animal models, primarily by interfering with viral attachment and... |
| Reishi | Synergy | Ganoderma lucidum (Reishi) polysaccharides have antiviral activity against HSV-1 and HSV-2 in vitro, and a small clinical study reported faster... |
| Vitamin C | Synergy | Vitamin C has in vitro antiviral activity against HSV and supports immune function, and a topical ascorbate solution showed modest benefit in... |
| Zinc | Synergy | Topical zinc sulfate has shown benefit for recurrent herpes labialis in small placebo-controlled trials, and zinc has well-documented... |
The full acyclovir profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common acyclovir questions.
Quick answers drawn from the tables above.
What interacts with Acyclovir?
In the NutriStack database, Acyclovir has 5 documented interactions. The most notable include L-Lysine, Quercetin, Reishi, Vitamin C, and Zinc. Check any specific combination before taking it and confirm with your prescriber.
Is it safe to take L-Lysine with Acyclovir?
NutriStack classifies the L-Lysine and Acyclovir pairing as synergy: L-lysine is used by some patients as adjunctive prophylaxis against herpes simplex recurrences, working by a different mechanism than acyclovir. Evidence is mixed and... Lysine is reasonable as a complement to acyclovir for recurrent oral or genital HSV, typically at 1-3 g per day. Do not use it as a substitute for... Always confirm with your prescriber.
Check your whole stack
See how acyclovir fits your supplements.
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