Medication·Interactions·Reviewed June 9, 2026
Allopurinol interactions.
Allopurinol has 4 documented interactions in the NutriStack database, including 2 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Allopurinol at a glance.
A quick, data-grounded summary. The full tables are below.
Allopurinol has 4 documented interactions in the NutriStack database, including 2 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with allopurinol.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Alcohol | Conflict | Alcohol can trigger gout attacks and raise the urate burden that allopurinol is meant to control. Beer and spirits are the clearest concerns, and... details → |
| Vitamin B3 | Conflict | High-dose Vitamin B3 products that contain niacin or nicotinic acid can raise uric acid and have been associated with drug-induced gout. This can... details → |
| Iron | Caution | The interaction between allopurinol and iron is primarily theoretical. In animal studies, allopurinol increased hepatic iron storage by inhibiting... |
| Vitamin C | Synergy | Allopurinol promotes oxidative stress that can deplete plasma ascorbate levels. Vitamin C supplementation may help offset this depletion and provide... details → |
The full allopurinol profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common allopurinol questions.
Quick answers drawn from the tables above.
What interacts with Allopurinol?
In the NutriStack database, Allopurinol has 4 documented interactions. The most notable include Alcohol, Vitamin B3, Iron, and Vitamin C. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Allopurinol?
Allopurinol is flagged against 2 substances in the database, including Alcohol and Vitamin B3. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take Alcohol with Allopurinol?
NutriStack classifies the Alcohol and Allopurinol pairing as conflict: Alcohol can trigger gout attacks and raise the urate burden that allopurinol is meant to control. Beer and spirits are the clearest concerns, and even short-term... Limit or avoid alcohol while using allopurinol, especially during dose titration or if flares are still occurring. If you drink, keep intake low,... Always confirm with your prescriber.
Check your whole stack
See how allopurinol fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.