Medication·Interactions·Reviewed June 9, 2026
Alprazolam interactions.
Alprazolam has 9 documented interactions in the NutriStack database, including 3 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Alprazolam at a glance.
A quick, data-grounded summary. The full tables are below.
Alprazolam has 9 documented interactions in the NutriStack database, including 3 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with alprazolam.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Alcohol | Contraindicated | Alcohol can sharply amplify alprazolam's sedating and coordination-impairing effects. The combination increases risk of blackouts, falls, motor... details → |
| Hydrocodone | Contraindicated | FDA Black Box Warning: The combination of hydrocodone and alprazolam carries severe risk of fatal respiratory depression. This is among the most... details → |
| Oxycodone | Contraindicated | FDA Black Box Warning: Concurrent use of opioids and benzodiazepines can result in profound sedation, respiratory depression, coma, and death. This... details → |
| Bacopa Monnieri | Caution | Bacopa Monnieri extract inhibited CYP3A4 in vitro, and alprazolam exposure is clinically increased by CYP3A inhibition. Human data proving a... |
| GABA | Caution | Supplemental GABA may have mild sedative and anxiolytic effects, though its ability to cross the blood-brain barrier is debated. If any GABA does... |
| Melatonin | Caution | Melatonin has mild sedative properties that can add to alprazolam's CNS depressant effects. While the interaction is generally less dangerous than... details → |
| Passionflower | Caution | Passionflower has measurable anxiolytic and GABA-related CNS activity. Alprazolam is a benzodiazepine sedative, so the combination may cause more... |
| St. John's Wort | Caution | St. John's Wort can induce CYP3A4, the main enzyme clearing alprazolam. High-hyperforin St. John's Wort products may lower alprazolam exposure and... details → |
| Valerian Root | Caution | Valerian root has GABAergic sedative properties that can potentiate alprazolam's CNS depressant effects. The combination may cause excessive... details → |
The full alprazolam profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common alprazolam questions.
Quick answers drawn from the tables above.
What interacts with Alprazolam?
In the NutriStack database, Alprazolam has 9 documented interactions. The most notable include Alcohol, Hydrocodone, Oxycodone, Bacopa Monnieri, and GABA. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Alprazolam?
Alprazolam is flagged against 3 substances in the database, including Alcohol, Hydrocodone, and Oxycodone. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take Alcohol with Alprazolam?
NutriStack classifies the Alcohol and Alprazolam pairing as contraindicated: Alcohol can sharply amplify alprazolam's sedating and coordination-impairing effects. The combination increases risk of blackouts, falls, motor vehicle crashes,... Do not drink alcohol while taking alprazolam. If you drank recently, avoid non-urgent alprazolam dosing and ask your prescriber or pharmacist for... Always confirm with your prescriber.
Check your whole stack
See how alprazolam fits your supplements.
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