Medication·Interactions·Reviewed June 9, 2026
Amiodarone interactions.
Amiodarone has 8 documented interactions in the NutriStack database, including 2 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Amiodarone at a glance.
A quick, data-grounded summary. The full tables are below.
Amiodarone has 8 documented interactions in the NutriStack database, including 2 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with amiodarone.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Ciprofloxacin | Contraindicated | Both amiodarone and fluoroquinolones independently prolong the QT interval. Concurrent use creates additive QT prolongation risk, potentially... details → |
| St. John's Wort | Conflict | St. John's Wort induces CYP3A4, which is a major metabolic pathway for amiodarone. This can significantly reduce amiodarone plasma levels,... details → |
| Digoxin | Caution | Amiodarone increases digoxin levels by 70-100% through inhibition of P-glycoprotein and reduction of renal and non-renal clearance. This can cause... details → |
| Escitalopram | Caution | Both amiodarone and escitalopram can prolong the QT interval. Combined use increases the risk of dangerous cardiac arrhythmias, particularly... details → |
| Iodine | Caution | Amiodarone contains a large iodine load and is strongly associated with thyroid dysfunction. Extra iodine from supplements can further increase... details → |
| Coenzyme Q10 Ubiquinol | Synergy | Amiodarone has mitochondrial effects, and CoQ10 is involved in mitochondrial electron transport. Direct evidence that CoQ10 changes amiodarone... |
| Magnesium Glycinate | Synergy | Amiodarone can prolong cardiac repolarization, and low magnesium makes torsades de pointes more likely. Maintaining normal magnesium status helps... details → |
| Potassium | Synergy | Amiodarone can prolong the QT interval and rarely trigger torsades de pointes. Low potassium greatly increases that risk because it reduces the... details → |
The full amiodarone profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common amiodarone questions.
Quick answers drawn from the tables above.
What interacts with Amiodarone?
In the NutriStack database, Amiodarone has 8 documented interactions. The most notable include Ciprofloxacin, St. John's Wort, Digoxin, Escitalopram, and Iodine. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Amiodarone?
Amiodarone is flagged against 2 substances in the database, including Ciprofloxacin and St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take Ciprofloxacin with Amiodarone?
NutriStack classifies the Ciprofloxacin and Amiodarone pairing as contraindicated: Both amiodarone and fluoroquinolones independently prolong the QT interval. Concurrent use creates additive QT prolongation risk, potentially leading to torsades de... Avoid concurrent use if possible. If unavoidable, perform baseline ECG, monitor QTc closely, and discontinue if QTc exceeds 500 ms. Ensure... Always confirm with your prescriber.
Check your whole stack
See how amiodarone fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.