Medication·Interactions·Reviewed June 9, 2026
Amlodipine interactions.
Amlodipine has 14 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Amlodipine at a glance.
A quick, data-grounded summary. The full tables are below.
Amlodipine has 14 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with amlodipine.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| St. John's Wort | Conflict | St. John's Wort is a potent inducer of CYP3A4 via pregnane X receptor (PXR) activation. Amlodipine is primarily metabolized by CYP3A4.... details → |
| Berberine | Caution | Berberine is a clinically demonstrated inhibitor of CYP3A4, the main enzyme that clears amlodipine. Co-administration can raise amlodipine plasma... details → |
| Curcumin Phytosome | Caution | Curcumin phytosome formulations achieve 20-30 times higher plasma curcumin levels than standard curcumin, which magnifies any CYP3A4-mediated drug... |
| Garlic Extract | Caution | Aged garlic extract reduces systolic and diastolic blood pressure by about 8 and 5 mmHg in hypertensive patients in meta-analysis. Added on top of... details → |
| L-Arginine | Caution | L-Arginine is a nitric oxide precursor that lowers systolic and diastolic blood pressure by about 5/3 mmHg in meta-analysis. Combined with... details → |
| L-Citrulline | Caution | L-Citrulline is converted to L-arginine and raises plasma arginine more efficiently than oral arginine itself, producing nitric-oxide-mediated... details → |
| Magnesium Citrate | Caution | Magnesium acts as a physiologic calcium-channel modulator and lowers blood pressure by about 2 mmHg systolic and 1.8 mmHg diastolic at supplemental... details → |
| Magnesium Glycinate | Caution | Both amlodipine and magnesium act as calcium channel blockers through related mechanisms, creating additive hypotensive effects. Amlodipine blocks... details → |
| Quercetin | Caution | Quercetin, a flavonoid found in grapefruit and many supplements, inhibits CYP3A4 and intestinal P-glycoprotein in vitro. Amlodipine is a CYP3A4... details → |
| Turmeric/Curcumin | Caution | Curcumin inhibits CYP3A4 and intestinal P-glycoprotein, both of which contribute to amlodipine clearance and absorption. In a rat pharmacokinetic... |
| Coenzyme Q10 | Synergy | CoQ10 produces a small but consistent reduction in systolic blood pressure (about 3-5 mmHg) and improves endothelial function, complementing... details → |
| Coenzyme Q10 Ubiquinol | Synergy | Ubiquinol is the reduced, more bioavailable form of CoQ10 and produces the same modest blood-pressure-lowering and endothelial benefits as... details → |
| Fish Oil | Synergy | Omega-3 fatty acids in fish oil produce small but consistent reductions in blood pressure (about 2-3 mmHg systolic at doses of 2-3 g/day) and lower... details → |
| Vitamin D3 | Synergy | In patients with documented vitamin D deficiency and hypertension, vitamin D supplementation produces a small additional reduction in systolic and... details → |
The full amlodipine profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common amlodipine questions.
Quick answers drawn from the tables above.
What interacts with Amlodipine?
In the NutriStack database, Amlodipine has 14 documented interactions. The most notable include St. John's Wort, Berberine, Curcumin Phytosome, Garlic Extract, and L-Arginine. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Amlodipine?
Amlodipine is flagged against 1 substance in the database, including St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take St. John's Wort with Amlodipine?
NutriStack classifies the St. John's Wort and Amlodipine pairing as conflict: St. John's Wort is a potent inducer of CYP3A4 via pregnane X receptor (PXR) activation. Amlodipine is primarily metabolized by CYP3A4. Co-administration can... Avoid combining St. John's Wort with amlodipine. If currently taking both, consult your prescriber before making changes. Abruptly stopping St.... Always confirm with your prescriber.
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