Medication·Interactions·Reviewed June 9, 2026
Amphetamine/Dextroamphetamine interactions.
Amphetamine/Dextroamphetamine has 5 documented interactions in the NutriStack database, including 2 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Amphetamine/Dextroamphetamine at a glance.
A quick, data-grounded summary. The full tables are below.
Amphetamine/Dextroamphetamine has 5 documented interactions in the NutriStack database, including 2 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with amphetamine/dextroamphetamine.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Cocaine | Contraindicated | Cocaine and amphetamine/dextroamphetamine are both sympathomimetic stimulants. Using them together can intensify tachycardia, hypertension, coronary... details → |
| MDMA | Contraindicated | MDMA is a substituted amphetamine with strong serotonin, norepinephrine, and dopamine releasing effects. Combining it with... details → |
| Alcohol | Caution | Amphetamine/dextroamphetamine can partially counter alcohol-related psychomotor slowing without making the person sober. This can make intoxication... details → |
| Nicotine | Caution | Nicotine can add sympathetic stimulation to amphetamine/dextroamphetamine and may also reinforce stimulant use patterns. The combination can worsen... |
| Vitamin C | Timing Sensitive | High-dose Vitamin C products are usually ascorbic acid, and acidifying conditions can lower amphetamine blood levels by increasing renal clearance... details → |
The full amphetamine/dextroamphetamine profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common amphetamine/dextroamphetamine questions.
Quick answers drawn from the tables above.
What interacts with Amphetamine/Dextroamphetamine?
In the NutriStack database, Amphetamine/Dextroamphetamine has 5 documented interactions. The most notable include Cocaine, MDMA, Alcohol, Nicotine, and Vitamin C. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Amphetamine/Dextroamphetamine?
Amphetamine/Dextroamphetamine is flagged against 2 substances in the database, including Cocaine and MDMA. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take Cocaine with Amphetamine/Dextroamphetamine?
NutriStack classifies the Cocaine and Amphetamine/Dextroamphetamine pairing as contraindicated: Cocaine and amphetamine/dextroamphetamine are both sympathomimetic stimulants. Using them together can intensify tachycardia, hypertension, coronary vasospasm,... Do not use cocaine while taking amphetamine/dextroamphetamine. If cocaine exposure occurs, do not take extra stimulant doses and avoid exercise or... Always confirm with your prescriber.
Check your whole stack
See how amphetamine/dextroamphetamine fits your supplements.
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