Medication·Interactions·Reviewed June 9, 2026
Calcitriol interactions.
Calcitriol has 4 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Calcitriol at a glance.
A quick, data-grounded summary. The full tables are below.
Calcitriol has 4 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with calcitriol.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Vitamin D3 | Contraindicated | Additional vitamin D can increase the risk of vitamin D toxicity and hypercalcemia during calcitriol therapy. |
| Calcium | Caution | Calcium supplements can combine with calcitriol to cause hypercalcemia, hypercalciuria, kidney stones, or soft tissue calcification. |
| Magnesium Glycinate | Caution | Magnesium supplements can contribute to hypermagnesemia in advanced kidney disease, and calcitriol is often used in kidney-related mineral disorders. |
| Vitamin K2 | Synergy | Vitamin K2 is sometimes used to support calcium-handling proteins, but it does not prevent calcitriol-induced hypercalcemia. |
The full calcitriol profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common calcitriol questions.
Quick answers drawn from the tables above.
What interacts with Calcitriol?
In the NutriStack database, Calcitriol has 4 documented interactions. The most notable include Vitamin D3, Calcium, Magnesium Glycinate, and Vitamin K2. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Calcitriol?
Calcitriol is flagged against 1 substance in the database, including Vitamin D3. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take Vitamin D3 with Calcitriol?
NutriStack classifies the Vitamin D3 and Calcitriol pairing as contraindicated: Additional vitamin D can increase the risk of vitamin D toxicity and hypercalcemia during calcitriol therapy. Do not add vitamin D supplements unless the prescriber specifically orders them and monitors calcium and vitamin D status. Always confirm with your prescriber.
Check your whole stack
See how calcitriol fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.