Medication·Interactions·Reviewed June 9, 2026
Celecoxib interactions.
Celecoxib has 8 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Celecoxib at a glance.
A quick, data-grounded summary. The full tables are below.
Celecoxib has 8 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with celecoxib.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Alcohol | Caution | Celecoxib generally causes fewer upper GI ulcers than many nonselective NSAIDs, but alcohol can still increase GI irritation and bleeding risk. The... details → |
| Curcumin Phytosome | Caution | Curcumin phytosome may add antiplatelet activity to celecoxib in people with additional bleeding risks. Celecoxib is less platelet-active than many... |
| Fish Oil | Caution | Fish oil has mild antiplatelet effects and may add bleeding risk to celecoxib in higher-risk situations. Modern randomized-trial evidence suggests... details → |
| Ginkgo Biloba | Caution | Ginkgo biloba may add bleeding risk to celecoxib, particularly in people who also take aspirin or have ulcer history. Celecoxib is more GI-sparing... |
| Nattokinase | Caution | Nattokinase may add fibrinolytic effects to celecoxib-related bleeding risk, especially when celecoxib is used with aspirin or in patients with... |
| Potassium | Caution | Celecoxib can still affect kidney prostaglandins and potassium balance despite its COX-2 selectivity. Potassium supplements increase the potassium... details → |
| Resveratrol | Caution | Resveratrol may increase celecoxib exposure and also has antiplatelet effects, creating a plausible safety concern. A human pharmacokinetic study... |
| Turmeric/Curcumin | Caution | Both celecoxib and curcumin inhibit COX-2. Combined use may provide additive anti-inflammatory effects but also increases the risk of GI and... |
The full celecoxib profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common celecoxib questions.
Quick answers drawn from the tables above.
What interacts with Celecoxib?
In the NutriStack database, Celecoxib has 8 documented interactions. The most notable include Alcohol, Curcumin Phytosome, Fish Oil, Ginkgo Biloba, and Nattokinase. Check any specific combination before taking it and confirm with your prescriber.
Is it safe to take Alcohol with Celecoxib?
NutriStack classifies the Alcohol and Celecoxib pairing as caution: Celecoxib generally causes fewer upper GI ulcers than many nonselective NSAIDs, but alcohol can still increase GI irritation and bleeding risk. The risk becomes more... Avoid heavy alcohol use while taking celecoxib. If you have ulcer history or take low-dose aspirin with celecoxib, ask your clinician whether you... Always confirm with your prescriber.
Check your whole stack
See how celecoxib fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.