Medication·Interactions·Reviewed June 9, 2026
Clomipramine interactions.
Clomipramine has 4 documented interactions in the NutriStack database, including 3 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Clomipramine at a glance.
A quick, data-grounded summary. The full tables are below.
Clomipramine has 4 documented interactions in the NutriStack database, including 3 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with clomipramine.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| 5-HTP | Contraindicated | 5-HTP increases serotonin synthesis and can precipitate serotonin syndrome with clomipramine. |
| L-Tryptophan | Contraindicated | Supplemental L-Tryptophan can increase serotonin production during clomipramine therapy. |
| St. John's Wort | Contraindicated | St. John's Wort can add serotonergic activity and can alter metabolism of many drugs. |
| Ginkgo Biloba | Caution | Ginkgo has case reports of seizures and may increase bleeding tendency. Clomipramine can lower seizure threshold and may increase bleeding risk... |
The full clomipramine profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common clomipramine questions.
Quick answers drawn from the tables above.
What interacts with Clomipramine?
In the NutriStack database, Clomipramine has 4 documented interactions. The most notable include 5-HTP, L-Tryptophan, St. John's Wort, and Ginkgo Biloba. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Clomipramine?
Clomipramine is flagged against 3 substances in the database, including 5-HTP, L-Tryptophan, and St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take 5-HTP with Clomipramine?
NutriStack classifies the 5-HTP and Clomipramine pairing as contraindicated: 5-HTP increases serotonin synthesis and can precipitate serotonin syndrome with clomipramine. Avoid 5-HTP with clomipramine. Always confirm with your prescriber.
Check your whole stack
See how clomipramine fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.