Medication·Interactions·Reviewed June 9, 2026
Clonazepam interactions.
Clonazepam has 4 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Clonazepam at a glance.
A quick, data-grounded summary. The full tables are below.
Clonazepam has 4 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with clonazepam.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Alcohol | Contraindicated | Alcohol adds to clonazepam's CNS-depressant effects and can produce marked drowsiness, slowed reaction time, ataxia, memory gaps, and respiratory... details → |
| Melatonin | Caution | Both promote sleep through different mechanisms. Combined sedation may cause excessive drowsiness. However, melatonin may help facilitate... details → |
| Passionflower | Caution | Passionflower can have calming CNS effects and GABA-related activity. Clonazepam is a long-acting benzodiazepine, so additive sedation may last... |
| Valerian Root | Caution | Both clonazepam and valerian act on GABA-A receptors. Combined use causes additive CNS depression, excessive sedation, and respiratory depression... details → |
The full clonazepam profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common clonazepam questions.
Quick answers drawn from the tables above.
What interacts with Clonazepam?
In the NutriStack database, Clonazepam has 4 documented interactions. The most notable include Alcohol, Melatonin, Passionflower, and Valerian Root. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Clonazepam?
Clonazepam is flagged against 1 substance in the database, including Alcohol. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take Alcohol with Clonazepam?
NutriStack classifies the Alcohol and Clonazepam pairing as contraindicated: Alcohol adds to clonazepam's CNS-depressant effects and can produce marked drowsiness, slowed reaction time, ataxia, memory gaps, and respiratory depression. Because... Avoid alcohol while taking clonazepam. Do not drive or operate machinery if any alcohol was used near a clonazepam dose. Seek emergency care for... Always confirm with your prescriber.
Check your whole stack
See how clonazepam fits your supplements.
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