Medication·Interactions·Reviewed June 9, 2026
Clozapine interactions.
Clozapine has 4 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Clozapine at a glance.
A quick, data-grounded summary. The full tables are below.
Clozapine has 4 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with clozapine.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| St. John's Wort | Conflict | St. John's Wort induces drug-metabolizing enzymes and transporters and may lower exposure to some antipsychotics or destabilize psychiatric treatment. |
| Ashwagandha | Caution | Ashwagandha can be sedating in some patients and may add to clozapine-related somnolence or orthostatic symptoms. |
| Ginkgo Biloba | Caution | Ginkgo has seizure case reports, and clozapine has a dose-related seizure boxed warning. |
| Melatonin | Caution | Melatonin can add to clozapine-related sedation, dizziness, and impaired coordination. |
The full clozapine profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common clozapine questions.
Quick answers drawn from the tables above.
What interacts with Clozapine?
In the NutriStack database, Clozapine has 4 documented interactions. The most notable include St. John's Wort, Ashwagandha, Ginkgo Biloba, and Melatonin. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Clozapine?
Clozapine is flagged against 1 substance in the database, including St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take St. John's Wort with Clozapine?
NutriStack classifies the St. John's Wort and Clozapine pairing as conflict: St. John's Wort induces drug-metabolizing enzymes and transporters and may lower exposure to some antipsychotics or destabilize psychiatric treatment. Avoid St. John's Wort unless the psychiatric prescriber explicitly approves and clozapine response is monitored closely. Always confirm with your prescriber.
Check your whole stack
See how clozapine fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.