Medication·Interactions·Reviewed June 9, 2026
Diazepam interactions.
Diazepam has 5 documented interactions in the NutriStack database, including 3 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Diazepam at a glance.
A quick, data-grounded summary. The full tables are below.
Diazepam has 5 documented interactions in the NutriStack database, including 3 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with diazepam.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Alcohol | Contraindicated | Alcohol and diazepam together produce additive psychomotor impairment, slowed reactions, memory problems, and excessive sedation. Diazepam and its... details → |
| Morphine | Contraindicated | FDA Black Box Warning: Concurrent opioid and benzodiazepine use can result in profound sedation, respiratory depression, coma, and death. Morphine... details → |
| St. John's Wort | Conflict | St. John's Wort induces CYP3A4 and CYP2C19, both of which metabolize diazepam. This can reduce diazepam levels, causing breakthrough anxiety or... details → |
| Apigenin | Caution | Apigenin has benzodiazepine-receptor and GABA(A)-modulating activity in preclinical studies. One receptor study specifically found that apigenin... |
| Valerian Root | Caution | Both diazepam and valerian enhance GABA-A receptor activity. Combined use creates additive CNS depression and excessive sedation. details → |
The full diazepam profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common diazepam questions.
Quick answers drawn from the tables above.
What interacts with Diazepam?
In the NutriStack database, Diazepam has 5 documented interactions. The most notable include Alcohol, Morphine, St. John's Wort, Apigenin, and Valerian Root. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Diazepam?
Diazepam is flagged against 3 substances in the database, including Alcohol, Morphine, and St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take Alcohol with Diazepam?
NutriStack classifies the Alcohol and Diazepam pairing as contraindicated: Alcohol and diazepam together produce additive psychomotor impairment, slowed reactions, memory problems, and excessive sedation. Diazepam and its active metabolites... Do not drink alcohol while taking diazepam. Avoid driving if you have taken diazepam and consumed alcohol within the same day. Get urgent help if... Always confirm with your prescriber.
Check your whole stack
See how diazepam fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.