Medication·Interactions·Reviewed June 9, 2026
Diclofenac interactions.
Diclofenac has 8 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Diclofenac at a glance.
A quick, data-grounded summary. The full tables are below.
Diclofenac has 8 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with diclofenac.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Alcohol | Caution | Alcohol can increase diclofenac-related gastrointestinal bleeding risk. Diclofenac reduces protective gastric prostaglandins, and alcohol can... details → |
| Curcumin Phytosome | Caution | Curcumin phytosome may add antiplatelet effects to diclofenac's NSAID bleeding risk. Phytosome formulations are intended to improve curcumin... |
| Fish Oil | Caution | High-dose fish oil may add mild antiplatelet effects to diclofenac's GI bleeding risk. Standard omega-3 doses usually do not cause major bleeding in... details → |
| Garlic Extract | Caution | Concentrated garlic extract may increase bleeding tendency when combined with diclofenac. Diclofenac can injure the GI lining, while garlic... |
| Ginkgo Biloba | Caution | Ginkgo biloba may increase bleeding risk with diclofenac. Ginkgo has reported spontaneous bleeding cases, and diclofenac can cause NSAID-related GI... |
| Nattokinase | Caution | Nattokinase may compound diclofenac-related bleeding risk through fibrinolytic and anticoagulant effects. Diclofenac can cause NSAID-related GI... |
| Potassium | Caution | Diclofenac can impair kidney potassium excretion, and potassium supplements can make hyperkalemia more likely. Risk is higher during dehydration or... details → |
| Turmeric/Curcumin | Caution | Concentrated turmeric/curcumin may add antiplatelet effects to diclofenac's GI bleeding risk. Diclofenac can cause NSAID-related erosions or ulcers,... |
The full diclofenac profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common diclofenac questions.
Quick answers drawn from the tables above.
What interacts with Diclofenac?
In the NutriStack database, Diclofenac has 8 documented interactions. The most notable include Alcohol, Curcumin Phytosome, Fish Oil, Garlic Extract, and Ginkgo Biloba. Check any specific combination before taking it and confirm with your prescriber.
Is it safe to take Alcohol with Diclofenac?
NutriStack classifies the Alcohol and Diclofenac pairing as caution: Alcohol can increase diclofenac-related gastrointestinal bleeding risk. Diclofenac reduces protective gastric prostaglandins, and alcohol can directly damage the... Avoid heavy alcohol use while taking diclofenac. Use the lowest effective dose for the shortest time and seek care promptly for black stools,... Always confirm with your prescriber.
Check your whole stack
See how diclofenac fits your supplements.
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