Medication·Interactions·Reviewed June 9, 2026
Digoxin interactions.
Digoxin has 10 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Digoxin at a glance.
A quick, data-grounded summary. The full tables are below.
Digoxin has 10 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with digoxin.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| St. John's Wort | Conflict | St. John's Wort significantly reduces digoxin levels through potent P-glycoprotein induction. A landmark study showed that St. John's Wort reduced... details → |
| Amiodarone | Caution | Amiodarone increases digoxin levels by 70-100% through inhibition of P-glycoprotein and reduction of renal and non-renal clearance. This can cause... details → |
| Berberine | Caution | Berberine may increase oral digoxin exposure by inhibiting intestinal P-glycoprotein. Digoxin has a narrow therapeutic index, so even moderate... |
| Berberine HCl | Caution | Berberine inhibits P-glycoprotein, increasing digoxin bioavailability. Digoxin has a narrow therapeutic index. details → |
| Calcium | Caution | Large or repeated calcium supplement doses can cause hypercalcemia in susceptible people, particularly with kidney disease, dehydration, thiazide... details → |
| Magnesium Glycinate | Caution | Hypomagnesemia increases sensitivity to digoxin toxicity by altering the cardiac sodium-potassium ATPase that digoxin inhibits. Maintaining adequate... details → |
| Potassium | Caution | Hypokalemia dramatically increases the risk of digoxin toxicity, including life-threatening cardiac arrhythmias. Conversely, hyperkalemia with... details → |
| Vitamin D3 | Caution | High-dose vitamin D3 can cause hypercalcemia, and hypercalcemia can make digoxin-related rhythm problems more likely. This is not a routine-dose... details → |
| Activated Charcoal | Timing Sensitive | Activated charcoal binds digoxin in the gastrointestinal tract and can sharply reduce absorption when taken near a dose. Because digoxin has a... details → |
| Psyllium Husk | Timing Sensitive | Psyllium husk is a bulk-forming fiber similar to ispaghula, which has reduced digoxin bioavailability in human studies. Taking psyllium close to... details → |
The full digoxin profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common digoxin questions.
Quick answers drawn from the tables above.
What interacts with Digoxin?
In the NutriStack database, Digoxin has 10 documented interactions. The most notable include St. John's Wort, Amiodarone, Berberine, Berberine HCl, and Calcium. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Digoxin?
Digoxin is flagged against 1 substance in the database, including St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take St. John's Wort with Digoxin?
NutriStack classifies the St. John's Wort and Digoxin pairing as conflict: St. John's Wort significantly reduces digoxin levels through potent P-glycoprotein induction. A landmark study showed that St. John's Wort reduced digoxin AUC by 25%,... Do not combine St. John's Wort with digoxin. The reduction in digoxin levels can lead to loss of rate control or worsening heart failure. If already... Always confirm with your prescriber.
Check your whole stack
See how digoxin fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.