Medication·Interactions·Reviewed June 9, 2026
Donepezil interactions.
Donepezil has 3 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Donepezil at a glance.
A quick, data-grounded summary. The full tables are below.
Donepezil has 3 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with donepezil.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Alpha-GPC | Caution | Both donepezil and Alpha-GPC increase cholinergic activity. Donepezil inhibits acetylcholinesterase; Alpha-GPC provides choline for acetylcholine... |
| Ginkgo Biloba | Caution | Both donepezil and ginkgo biloba have cholinergic and cognitive effects. Some studies have explored the combination, but additive cholinergic side... details → |
| Citicoline | Synergy | Citicoline has been studied as an adjunct to acetylcholinesterase inhibitors such as donepezil in Alzheimer's disease. Observational data and a... details → |
The full donepezil profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common donepezil questions.
Quick answers drawn from the tables above.
What interacts with Donepezil?
In the NutriStack database, Donepezil has 3 documented interactions. The most notable include Alpha-GPC, Ginkgo Biloba, and Citicoline. Check any specific combination before taking it and confirm with your prescriber.
Is it safe to take Alpha-GPC with Donepezil?
NutriStack classifies the Alpha-GPC and Donepezil pairing as caution: Both donepezil and Alpha-GPC increase cholinergic activity. Donepezil inhibits acetylcholinesterase; Alpha-GPC provides choline for acetylcholine synthesis. Combined... If combining, start Alpha-GPC at low doses (300mg) and monitor for cholinergic side effects (nausea, diarrhea, muscle cramps, bradycardia). Always confirm with your prescriber.
Check your whole stack
See how donepezil fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.