Medication·Interactions·Reviewed June 9, 2026
Doxepin interactions.
Doxepin has 4 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Doxepin at a glance.
A quick, data-grounded summary. The full tables are below.
Doxepin has 4 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with doxepin.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| St. John's Wort | Conflict | St. John's Wort can add serotonergic effects and alter metabolism of many drugs. |
| 5-HTP | Caution | At antidepressant doses, doxepin has serotonin reuptake effects; 5-HTP can increase serotonin synthesis. |
| L-Theanine | Caution | L-Theanine may have calming or sedating effects that can add to doxepin. |
| Melatonin | Caution | Melatonin can add to doxepin-related sedation and next-day impairment. |
The full doxepin profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common doxepin questions.
Quick answers drawn from the tables above.
What interacts with Doxepin?
In the NutriStack database, Doxepin has 4 documented interactions. The most notable include St. John's Wort, 5-HTP, L-Theanine, and Melatonin. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Doxepin?
Doxepin is flagged against 1 substance in the database, including St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take St. John's Wort with Doxepin?
NutriStack classifies the St. John's Wort and Doxepin pairing as conflict: St. John's Wort can add serotonergic effects and alter metabolism of many drugs. Avoid combining with doxepin unless directed by the prescriber. Always confirm with your prescriber.
Check your whole stack
See how doxepin fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.