Medication·Interactions·Reviewed June 9, 2026
Felodipine interactions.
Felodipine has 6 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Felodipine at a glance.
A quick, data-grounded summary. The full tables are below.
Felodipine has 6 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with felodipine.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| St. John's Wort | Conflict | St. John's Wort is a potent inducer of intestinal and hepatic CYP3A4, the primary enzyme that metabolizes felodipine, which already has very low... |
| Garlic Extract | Caution | Garlic supplements have modest blood-pressure-lowering activity and can add to the antihypertensive effect of felodipine. The combined effect is... |
| Green Tea Extract | Caution | Green tea catechins can inhibit intestinal organic anion transporting polypeptides and may modestly affect CYP3A4 and P-glycoprotein, with the... |
| L-Citrulline | Caution | L-Citrulline may add to the blood-pressure-lowering effect of Felodipine. |
| Magnesium Glycinate | Caution | Magnesium Glycinate may add to the blood-pressure-lowering effect of Felodipine. |
| Quercetin | Caution | Quercetin inhibits CYP3A4 and P-glycoprotein in laboratory and some clinical studies. Because felodipine is a sensitive CYP3A4 substrate with low... |
The full felodipine profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common felodipine questions.
Quick answers drawn from the tables above.
What interacts with Felodipine?
In the NutriStack database, Felodipine has 6 documented interactions. The most notable include St. John's Wort, Garlic Extract, Green Tea Extract, L-Citrulline, and Magnesium Glycinate. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Felodipine?
Felodipine is flagged against 1 substance in the database, including St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take St. John's Wort with Felodipine?
NutriStack classifies the St. John's Wort and Felodipine pairing as conflict: St. John's Wort is a potent inducer of intestinal and hepatic CYP3A4, the primary enzyme that metabolizes felodipine, which already has very low oral bioavailability... Avoid combining St. John's Wort with felodipine. If a patient is already taking St. John's Wort, do not start it during felodipine therapy, and if... Always confirm with your prescriber.
Check your whole stack
See how felodipine fits your supplements.
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