Medication·Interactions·Reviewed June 9, 2026
Fluconazole interactions.
Fluconazole has 11 documented interactions in the NutriStack database, including 2 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Fluconazole at a glance.
A quick, data-grounded summary. The full tables are below.
Fluconazole has 11 documented interactions in the NutriStack database, including 2 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with fluconazole.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Saccharomyces Boulardii | Conflict | Saccharomyces boulardii is itself a yeast (a non-pathogenic strain of S. cerevisiae). Fluconazole has variable activity against Saccharomyces... |
| St. John's Wort | Conflict | St. John's Wort is a strong inducer of CYP3A4 (via PXR activation by hyperforin) and P-glycoprotein. Because fluconazole is partly metabolized by... details → |
| Alcohol | Caution | Fluconazole is hepatotoxic in a dose- and duration-dependent fashion, and alcohol is one of the strongest modifiable risk factors for drug-induced... details → |
| Berberine | Caution | Berberine inhibits CYP3A4 (and to a lesser extent CYP2D6), the same family of enzymes that fluconazole also inhibits. Stacking two CYP3A4 inhibitors... |
| Milk Thistle | Caution | Silymarin from milk thistle inhibits CYP3A4, CYP2C9, UGT enzymes, and P-glycoprotein in vitro, and clinical pharmacokinetic studies have shown... |
| Quercetin | Caution | Quercetin inhibits CYP3A4 and P-glycoprotein in vitro and has altered the pharmacokinetics of CYP3A4 substrates in animal models. Used alongside... |
| Resveratrol | Caution | Resveratrol inhibits CYP3A4 in vitro and in animal pharmacokinetic studies, where it has raised plasma exposure of CYP3A4 substrates such as... |
| Turmeric/Curcumin | Caution | Curcumin inhibits CYP3A4 and P-glycoprotein in vitro and has altered the pharmacokinetics of CYP3A4 substrates such as amlodipine and budesonide in... |
| Magnesium Glycinate | Synergy | Fluconazole can prolong the QT interval, especially at higher doses, in renal impairment, or with other QT-prolonging drugs. Low magnesium and low... details → |
| NAC | Synergy | Fluconazole can cause hepatotoxicity ranging from mild transaminase elevations to acute liver injury. N-acetylcysteine replenishes glutathione and... |
| Potassium | Synergy | Hypokalemia is a major risk factor for QT prolongation and torsades de pointes, and fluconazole independently prolongs the QT interval. Patients on... details → |
The full fluconazole profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common fluconazole questions.
Quick answers drawn from the tables above.
What interacts with Fluconazole?
In the NutriStack database, Fluconazole has 11 documented interactions. The most notable include Saccharomyces Boulardii, St. John's Wort, Alcohol, Berberine, and Milk Thistle. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Fluconazole?
Fluconazole is flagged against 2 substances in the database, including Saccharomyces Boulardii and St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take Saccharomyces Boulardii with Fluconazole?
NutriStack classifies the Saccharomyces Boulardii and Fluconazole pairing as conflict: Saccharomyces boulardii is itself a yeast (a non-pathogenic strain of S. cerevisiae). Fluconazole has variable activity against Saccharomyces species and may suppress... Hold Saccharomyces boulardii during your fluconazole course. Resume a few days after finishing fluconazole if you still want probiotic support.... Always confirm with your prescriber.
Check your whole stack
See how fluconazole fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.