Medication·Interactions·Reviewed June 9, 2026
Fosfomycin interactions.
Fosfomycin has 6 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Fosfomycin at a glance.
A quick, data-grounded summary. The full tables are below.
Fosfomycin has 6 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with fosfomycin.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Calcium | Timing Sensitive | Oral fosfomycin tromethamine is a single-dose therapy whose efficacy depends on achieving adequate urinary concentrations. Calcium is a divalent... |
| Iron | Timing Sensitive | Oral iron salts are polyvalent cations known to chelate many antibiotics in the gut. Iron can plausibly bind fosfomycin and reduce its absorption,... |
| Magnesium Glycinate | Timing Sensitive | Magnesium is a divalent cation that can chelate fosfomycin within the gut, similar to the documented interaction with magnesium-containing antacids.... |
| Probiotics | Timing Sensitive | Fosfomycin can suppress or kill bacterial probiotic organisms if taken at the same time, although selected probiotics may lower... |
| Psyllium Husk | Timing Sensitive | Psyllium can delay or reduce absorption of some oral drugs if taken at the same time as Fosfomycin. |
| Zinc | Timing Sensitive | Zinc is a divalent cation that, like other metal cations, can chelate fosfomycin in the gut and reduce its absorption. This may lower the urinary... |
The full fosfomycin profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common fosfomycin questions.
Quick answers drawn from the tables above.
What interacts with Fosfomycin?
In the NutriStack database, Fosfomycin has 6 documented interactions. The most notable include Calcium, Iron, Magnesium Glycinate, Probiotics, and Psyllium Husk. Check any specific combination before taking it and confirm with your prescriber.
Is it safe to take Calcium with Fosfomycin?
NutriStack classifies the Calcium and Fosfomycin pairing as timing sensitive: Oral fosfomycin tromethamine is a single-dose therapy whose efficacy depends on achieving adequate urinary concentrations. Calcium is a divalent cation that can bind... Take the single fosfomycin dose on its own and avoid calcium supplements (or calcium-rich antacids and large dairy doses) for several hours around... Always confirm with your prescriber.
Check your whole stack
See how fosfomycin fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.