Medication·Interactions·Reviewed June 9, 2026
Glimepiride interactions.
Glimepiride has 7 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Glimepiride at a glance.
A quick, data-grounded summary. The full tables are below.
Glimepiride has 7 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with glimepiride.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Alpha-Lipoic Acid | Caution | Alpha-lipoic acid improves insulin sensitivity and lowers fasting glucose in type 2 diabetes meta-analyses. It has also been associated with insulin... details → |
| Berberine HCl | Caution | Berberine HCl can lower fasting glucose, post-meal glucose, and HbA1c in type 2 diabetes. Glimepiride forces pancreatic insulin release and can... details → |
| Chromium | Caution | Chromium improves insulin sensitivity, while glimepiride forces pancreatic insulin release. Combined, the additive effect on blood glucose can... details → |
| Fenugreek | Caution | Fenugreek extracts lower fasting glucose and HbA1c in type 2 diabetes meta-analyses. Glimepiride forces pancreatic insulin release. The additive... details → |
| Milk Thistle | Caution | Glimepiride is metabolized primarily by CYP2C9. Silymarin (milk thistle) inhibits CYP2C9 in vitro and has independent hypoglycemic activity. The... details → |
| Quercetin | Caution | Quercetin inhibits CYP2C9 in human studies. Glimepiride is metabolized primarily by CYP2C9. Concentrated quercetin supplements can raise glimepiride... details → |
| Vanadium | Caution | Vanadium salts have insulin-mimetic effects and have improved insulin sensitivity in small human diabetes studies. Glimepiride is a sulfonylurea... |
The full glimepiride profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common glimepiride questions.
Quick answers drawn from the tables above.
What interacts with Glimepiride?
In the NutriStack database, Glimepiride has 7 documented interactions. The most notable include Alpha-Lipoic Acid, Berberine HCl, Chromium, Fenugreek, and Milk Thistle. Check any specific combination before taking it and confirm with your prescriber.
Is it safe to take Alpha-Lipoic Acid with Glimepiride?
NutriStack classifies the Alpha-Lipoic Acid and Glimepiride pairing as caution: Alpha-lipoic acid improves insulin sensitivity and lowers fasting glucose in type 2 diabetes meta-analyses. It has also been associated with insulin autoimmune syndrome... If you take glimepiride, do not start ALA without telling your prescriber. Monitor fingerstick glucose more often (before meals and at bedtime)... Always confirm with your prescriber.
Check your whole stack
See how glimepiride fits your supplements.
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