Medication·Interactions·Reviewed June 9, 2026
Glipizide interactions.
Glipizide has 9 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Glipizide at a glance.
A quick, data-grounded summary. The full tables are below.
Glipizide has 9 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with glipizide.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Alpha-Lipoic Acid | Caution | Alpha-lipoic acid (ALA) improves insulin sensitivity and lowers fasting glucose and HbA1c in meta-analyses of diabetic patients. ALA has also... details → |
| Berberine | Caution | Both glipizide and berberine lower blood glucose. Glipizide stimulates insulin secretion; berberine activates AMPK. Combined use significantly... details → |
| Berberine HCl | Caution | Berberine HCl lowers blood glucose independently of sulfonylurea therapy. Glipizide can cause hypoglycemia by increasing insulin release, so adding... details → |
| Chromium | Caution | Chromium supplementation can lower fasting glucose and HbA1c in type 2 diabetes by improving insulin signaling. Stacked on top of a sulfonylurea... details → |
| Fenugreek | Caution | Fenugreek extracts lower fasting glucose and HbA1c in type 2 diabetes meta-analyses. Stacked on glipizide, which already forces pancreatic insulin... details → |
| Inositol | Caution | Myo-inositol and D-chiro-inositol improve insulin sensitivity and lower fasting glucose. Glipizide forces pancreatic insulin secretion. Combined,... |
| Milk Thistle | Caution | Glipizide is metabolized primarily by CYP2C9. Silymarin (milk thistle) inhibits CYP2C9 in vitro and has independent hypoglycemic activity... details → |
| Quercetin | Caution | Quercetin is a flavonoid that inhibits CYP2C9 in human studies (it reduced diclofenac CYP2C9-mediated metabolism at 500 mg twice daily). Glipizide... details → |
| Vanadium | Caution | Vanadium has insulin-like and insulin-sensitizing activity in PubMed-indexed human diabetes studies. Glipizide stimulates insulin release and can... |
The full glipizide profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common glipizide questions.
Quick answers drawn from the tables above.
What interacts with Glipizide?
In the NutriStack database, Glipizide has 9 documented interactions. The most notable include Alpha-Lipoic Acid, Berberine, Berberine HCl, Chromium, and Fenugreek. Check any specific combination before taking it and confirm with your prescriber.
Is it safe to take Alpha-Lipoic Acid with Glipizide?
NutriStack classifies the Alpha-Lipoic Acid and Glipizide pairing as caution: Alpha-lipoic acid (ALA) improves insulin sensitivity and lowers fasting glucose and HbA1c in meta-analyses of diabetic patients. ALA has also triggered insulin... If you take glipizide, do not start ALA without telling your prescriber. Monitor fingerstick glucose more often during the first 4 weeks and after... Always confirm with your prescriber.
Check your whole stack
See how glipizide fits your supplements.
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