Medication·Interactions·Reviewed June 9, 2026
Glyburide interactions.
Glyburide has 8 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Glyburide at a glance.
A quick, data-grounded summary. The full tables are below.
Glyburide has 8 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with glyburide.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Alpha-Lipoic Acid | Caution | Alpha-lipoic acid improves insulin sensitivity and has been reported to trigger insulin autoimmune syndrome (Hirata syndrome) with severe... details → |
| Berberine | Caution | Glyburide is a potent sulfonylurea with high hypoglycemia risk. Adding berberine's AMPK-mediated glucose lowering significantly increases this risk. details → |
| Berberine HCl | Caution | Berberine HCl has clinically measurable glucose-lowering activity. Glyburide is a sulfonylurea with a relatively high hypoglycemia risk, and the... details → |
| Chromium | Caution | Chromium and glyburide both lower blood glucose by different mechanisms. Glyburide is the longest-acting sulfonylurea on the US market and already... details → |
| Fenugreek | Caution | Fenugreek extracts lower fasting glucose and HbA1c in type 2 diabetes meta-analyses. Glyburide is the longest-acting US sulfonylurea and already... details → |
| Milk Thistle | Caution | A 6-month RCT in 59 patients found that adding silymarin 200 mg three times daily to glyburide improved HbA1c and postprandial glucose more than... details → |
| Quercetin | Caution | Quercetin inhibits CYP2C9 in human studies. Glyburide is metabolized by CYP2C9 (and CYP3A4) and is the longest-acting US sulfonylurea with the... details → |
| Vanadium | Caution | Vanadium has insulin-like effects and has improved glucose metabolism in small human studies. Glyburide is a longer-acting sulfonylurea with a... |
The full glyburide profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common glyburide questions.
Quick answers drawn from the tables above.
What interacts with Glyburide?
In the NutriStack database, Glyburide has 8 documented interactions. The most notable include Alpha-Lipoic Acid, Berberine, Berberine HCl, Chromium, and Fenugreek. Check any specific combination before taking it and confirm with your prescriber.
Is it safe to take Alpha-Lipoic Acid with Glyburide?
NutriStack classifies the Alpha-Lipoic Acid and Glyburide pairing as caution: Alpha-lipoic acid improves insulin sensitivity and has been reported to trigger insulin autoimmune syndrome (Hirata syndrome) with severe spontaneous hypoglycemia.... Avoid starting ALA on glyburide unless your prescriber agrees and arranges close monitoring. If you do combine them, check fasting and bedtime... Always confirm with your prescriber.
Check your whole stack
See how glyburide fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.