Medication·Interactions·Reviewed June 9, 2026
Hydrocodone interactions.
Hydrocodone has 4 documented interactions in the NutriStack database, including 2 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Hydrocodone at a glance.
A quick, data-grounded summary. The full tables are below.
Hydrocodone has 4 documented interactions in the NutriStack database, including 2 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with hydrocodone.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Alcohol | Contraindicated | Alcohol can dangerously amplify hydrocodone's sedating and breathing-slowing effects. The combination increases the risk of profound sleepiness,... details → |
| Alprazolam | Contraindicated | FDA Black Box Warning: The combination of hydrocodone and alprazolam carries severe risk of fatal respiratory depression. This is among the most... details → |
| Cannabis (THC-Dominant) | Caution | Direct hydrocodone-THC clinical studies are limited, but hydrocodone shares the opioid respiratory-depression and sedation liabilities studied with... |
| Valerian Root | Caution | Hydrocodone can cause sedation and respiratory depression, and valerian root may add CNS-depressant effects through GABAergic activity. Direct... |
The full hydrocodone profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common hydrocodone questions.
Quick answers drawn from the tables above.
What interacts with Hydrocodone?
In the NutriStack database, Hydrocodone has 4 documented interactions. The most notable include Alcohol, Alprazolam, Cannabis (THC-Dominant), and Valerian Root. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Hydrocodone?
Hydrocodone is flagged against 2 substances in the database, including Alcohol and Alprazolam. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take Alcohol with Hydrocodone?
NutriStack classifies the Alcohol and Hydrocodone pairing as contraindicated: Alcohol can dangerously amplify hydrocodone's sedating and breathing-slowing effects. The combination increases the risk of profound sleepiness, impaired coordination,... Do not drink alcohol while taking hydrocodone. If alcohol was used recently, skip non-urgent opioid dosing and contact your prescriber or pharmacist... Always confirm with your prescriber.
Check your whole stack
See how hydrocodone fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.