Medication·Interactions·Reviewed June 9, 2026
Hydroxyzine interactions.
Hydroxyzine has 3 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Hydroxyzine at a glance.
A quick, data-grounded summary. The full tables are below.
Hydroxyzine has 3 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with hydroxyzine.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Alcohol | Caution | Alcohol can markedly worsen hydroxyzine-related drowsiness, slowed reaction time, and clumsiness. In a controlled crossover trial, hydroxyzine taken... details → |
| Cannabis (THC-Dominant) | Caution | THC-dominant cannabis can compound hydroxyzine's sedating and attention-slowing effects. Hydroxyzine has measurable next-day and same-day cognitive... details → |
| Melatonin | Caution | Melatonin can add to hydroxyzine's sedating effects, especially when hydroxyzine is used at night for itching, anxiety, or sleep. Hydroxyzine can... |
The full hydroxyzine profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common hydroxyzine questions.
Quick answers drawn from the tables above.
What interacts with Hydroxyzine?
In the NutriStack database, Hydroxyzine has 3 documented interactions. The most notable include Alcohol, Cannabis (THC-Dominant), and Melatonin. Check any specific combination before taking it and confirm with your prescriber.
Is it safe to take Alcohol with Hydroxyzine?
NutriStack classifies the Alcohol and Hydroxyzine pairing as caution: Alcohol can markedly worsen hydroxyzine-related drowsiness, slowed reaction time, and clumsiness. In a controlled crossover trial, hydroxyzine taken with alcohol... Do not drink alcohol when taking hydroxyzine for allergy, itching, anxiety, or sleep. If you already drank, avoid non-urgent hydroxyzine dosing and... Always confirm with your prescriber.
Check your whole stack
See how hydroxyzine fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.