Medication·Interactions·Reviewed June 9, 2026
Ibuprofen interactions.
Ibuprofen has 10 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Ibuprofen at a glance.
A quick, data-grounded summary. The full tables are below.
Ibuprofen has 10 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with ibuprofen.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Alcohol | Caution | Alcohol increases the chance of stomach bleeding while taking ibuprofen. The combination is most concerning with repeated ibuprofen dosing, binge... details → |
| Apixaban | Caution | NSAIDs increase the bleeding risk when combined with DOACs through antiplatelet effects and GI mucosal irritation. While DOACs have fewer food/drug... details → |
| Fish Oil | Caution | Both ibuprofen and fish oil have antiplatelet effects. Combined use may modestly increase GI bleeding risk. However, the interaction is generally... details → |
| Garlic Extract | Caution | Concentrated garlic extract may add antiplatelet activity to ibuprofen's bleeding risk. This is most relevant with high-dose garlic products,... |
| Ginkgo Biloba | Caution | Ginkgo biloba may add antiplatelet effects to ibuprofen and has a published case of fatal intracerebral bleeding with ibuprofen. Ibuprofen also... details → |
| Methotrexate | Caution | NSAIDs reduce renal clearance of methotrexate, potentially leading to toxic methotrexate accumulation. This can cause severe bone marrow... details → |
| Nattokinase | Caution | Nattokinase has fibrinolytic and anticoagulant effects that may add to ibuprofen-related bleeding risk. Ibuprofen can irritate the GI tract and... |
| Potassium | Caution | Ibuprofen can reduce kidney potassium excretion, and potassium supplements can push serum potassium higher. This is most important if you have... details → |
| Turmeric/Curcumin | Caution | Concentrated turmeric/curcumin may add antiplatelet effects to ibuprofen's bleeding risk. Ibuprofen also increases upper GI injury risk, especially... |
| Warfarin | Caution | NSAIDs increase bleeding risk with warfarin through dual mechanisms: antiplatelet effects and GI mucosal damage. Ibuprofen also inhibits CYP2C9,... details → |
The full ibuprofen profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common ibuprofen questions.
Quick answers drawn from the tables above.
What interacts with Ibuprofen?
In the NutriStack database, Ibuprofen has 10 documented interactions. The most notable include Alcohol, Apixaban, Fish Oil, Garlic Extract, and Ginkgo Biloba. Check any specific combination before taking it and confirm with your prescriber.
Is it safe to take Alcohol with Ibuprofen?
NutriStack classifies the Alcohol and Ibuprofen pairing as caution: Alcohol increases the chance of stomach bleeding while taking ibuprofen. The combination is most concerning with repeated ibuprofen dosing, binge drinking, older age,... Avoid heavy drinking while using ibuprofen, and do not use ibuprofen to treat hangover symptoms after substantial alcohol intake. Use the lowest... Always confirm with your prescriber.
Check your whole stack
See how ibuprofen fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.