Medication·Interactions·Reviewed June 9, 2026
Icosapent Ethyl interactions.
Icosapent Ethyl has 5 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Icosapent Ethyl at a glance.
A quick, data-grounded summary. The full tables are below.
Icosapent Ethyl has 5 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with icosapent ethyl.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Fish Oil | Caution | Fish Oil may increase bleeding tendency and can be a concern with Icosapent Ethyl when additional omega-3 products increase total antiplatelet... |
| Garlic Extract | Caution | Garlic Extract may increase bleeding tendency and can be a concern with Icosapent Ethyl when garlic is combined with omega-3 therapy or... |
| Ginkgo Biloba | Caution | Ginkgo Biloba may increase bleeding tendency and can be a concern with Icosapent Ethyl when ginkgo is combined with omega-3 therapy or... |
| Vitamin E | Caution | Vitamin E may increase bleeding tendency and can be a concern with Icosapent Ethyl when high-dose vitamin E is combined with omega-3 therapy or... |
| Vitamin K1 | Timing Sensitive | Icosapent ethyl is a fatty acid ester that requires dietary fat for absorption, and fat-soluble vitamin K1 is similarly best absorbed with a... |
The full icosapent ethyl profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common icosapent ethyl questions.
Quick answers drawn from the tables above.
What interacts with Icosapent Ethyl?
In the NutriStack database, Icosapent Ethyl has 5 documented interactions. The most notable include Fish Oil, Garlic Extract, Ginkgo Biloba, Vitamin E, and Vitamin K1. Check any specific combination before taking it and confirm with your prescriber.
Is it safe to take Fish Oil with Icosapent Ethyl?
NutriStack classifies the Fish Oil and Icosapent Ethyl pairing as caution: Fish Oil may increase bleeding tendency and can be a concern with Icosapent Ethyl when additional omega-3 products increase total antiplatelet exposure. Avoid high-dose use unless the prescriber agrees; seek care for unusual bruising, bleeding, black stools, or severe headache. Always confirm with your prescriber.
Check your whole stack
See how icosapent ethyl fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.