Medication·Interactions·Reviewed June 9, 2026
Insulin Glargine interactions.
Insulin Glargine has 11 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Insulin Glargine at a glance.
A quick, data-grounded summary. The full tables are below.
Insulin Glargine has 11 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with insulin glargine.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Alpha-Lipoic Acid | Caution | Alpha-lipoic acid may improve insulin-mediated glucose disposal and has rare reports of insulin autoimmune syndrome with severe hypoglycemia.... |
| Berberine | Caution | Berberine can lower glucose through AMPK-linked metabolic effects and may improve insulin sensitivity. Because insulin glargine provides basal... details → |
| Berberine HCl | Caution | Berberine HCl can lower glucose through AMPK-linked metabolic effects and may improve insulin sensitivity. Because insulin glargine provides basal... details → |
| Chromium | Caution | Chromium may modestly improve insulin sensitivity in some people with diabetes or insulin resistance. Because insulin glargine provides basal... |
| Chromium Picolinate | Caution | Chromium picolinate may modestly improve insulin sensitivity in some people with diabetes or insulin resistance. Because insulin glargine provides... |
| Cinnamon Extract | Caution | Concentrated cinnamon extracts may modestly lower fasting or post-meal glucose in some studies. Because insulin glargine provides basal insulin... |
| Fenugreek | Caution | Fenugreek seed fiber and constituents may lower fasting or post-meal glucose in diabetes studies. Because insulin glargine provides basal insulin... details → |
| Inositol | Caution | Myo-inositol and D-chiro-inositol may improve insulin signaling and glucose handling. Because insulin glargine provides basal insulin exposure... |
| Vanadium | Caution | Vanadium salts have insulin-mimetic activity and small human studies show glucose-lowering or insulin-sensitizing effects. Because insulin glargine... |
| Magnesium Glycinate | Synergy | Magnesium repletion may gradually improve insulin signaling and glucose control when magnesium status is low. Because insulin glargine provides... details → |
| Vitamin D3 | Synergy | Vitamin D repletion may gradually improve insulin sensitivity when vitamin D status is low. Because insulin glargine provides basal insulin exposure... details → |
The full insulin glargine profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common insulin glargine questions.
Quick answers drawn from the tables above.
What interacts with Insulin Glargine?
In the NutriStack database, Insulin Glargine has 11 documented interactions. The most notable include Alpha-Lipoic Acid, Berberine, Berberine HCl, Chromium, and Chromium Picolinate. Check any specific combination before taking it and confirm with your prescriber.
Is it safe to take Alpha-Lipoic Acid with Insulin Glargine?
NutriStack classifies the Alpha-Lipoic Acid and Insulin Glargine pairing as caution: Alpha-lipoic acid may improve insulin-mediated glucose disposal and has rare reports of insulin autoimmune syndrome with severe hypoglycemia. Because insulin glargine... Do not start, stop, or substantially change Alpha-Lipoic Acid while using insulin glargine without diabetes-clinician awareness. Follow the... Always confirm with your prescriber.
Check your whole stack
See how insulin glargine fits your supplements.
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