Medication·Interactions·Reviewed June 9, 2026
Isosorbide Mononitrate interactions.
Isosorbide Mononitrate has 3 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Isosorbide Mononitrate at a glance.
A quick, data-grounded summary. The full tables are below.
Isosorbide Mononitrate has 3 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with isosorbide mononitrate.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| L-Arginine | Caution | Isosorbide mononitrate and L-arginine both increase nitric-oxide-mediated vasodilation. In a human crossover study, L-arginine enhanced the blood... details → |
| L-Citrulline | Caution | L-citrulline increases L-arginine availability and can lower blood pressure through nitric oxide pathways. Isosorbide mononitrate is an organic... details → |
| NAC | Caution | NAC may potentiate organic nitrate effects, increasing the chance of dizziness, severe headache, flushing, or symptomatic hypotension. Evidence is... details → |
The full isosorbide mononitrate profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common isosorbide mononitrate questions.
Quick answers drawn from the tables above.
What interacts with Isosorbide Mononitrate?
In the NutriStack database, Isosorbide Mononitrate has 3 documented interactions. The most notable include L-Arginine, L-Citrulline, and NAC. Check any specific combination before taking it and confirm with your prescriber.
Is it safe to take L-Arginine with Isosorbide Mononitrate?
NutriStack classifies the L-Arginine and Isosorbide Mononitrate pairing as caution: Isosorbide mononitrate and L-arginine both increase nitric-oxide-mediated vasodilation. In a human crossover study, L-arginine enhanced the blood pressure and... Do not add high-dose L-arginine to isosorbide mononitrate unless your prescriber is aware. If combined, check sitting and standing blood pressure... Always confirm with your prescriber.
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