Medication·Interactions·Reviewed June 9, 2026
Isotretinoin interactions.
Isotretinoin has 4 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Isotretinoin at a glance.
A quick, data-grounded summary. The full tables are below.
Isotretinoin has 4 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with isotretinoin.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Vitamin A | Contraindicated | Isotretinoin is a retinoid (13-cis-retinoic acid) that acts as a potent form of vitamin A. Adding supplemental vitamin A to isotretinoin therapy... details → |
| Alcohol | Caution | Isotretinoin can raise triglycerides and liver enzymes, usually modestly but occasionally to clinically important levels. Alcohol does not appear to... details → |
| Fish Oil | Synergy | Fish oil may help blunt isotretinoin-related triglyceride increases, especially if triglycerides are already elevated before treatment. Human data... details → |
| Fish Oil Triple Strength | Synergy | Concentrated fish oil may help control triglycerides during isotretinoin therapy. The evidence is based on omega-3 fatty acid and fish oil studies... details → |
The full isotretinoin profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common isotretinoin questions.
Quick answers drawn from the tables above.
What interacts with Isotretinoin?
In the NutriStack database, Isotretinoin has 4 documented interactions. The most notable include Vitamin A, Alcohol, Fish Oil, and Fish Oil Triple Strength. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Isotretinoin?
Isotretinoin is flagged against 1 substance in the database, including Vitamin A. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take Vitamin A with Isotretinoin?
NutriStack classifies the Vitamin A and Isotretinoin pairing as contraindicated: Isotretinoin is a retinoid (13-cis-retinoic acid) that acts as a potent form of vitamin A. Adding supplemental vitamin A to isotretinoin therapy creates severe... Do not take any vitamin A supplements, cod liver oil, or multivitamins containing vitamin A while on isotretinoin. This includes beta-carotene at... Always confirm with your prescriber.
Check your whole stack
See how isotretinoin fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.