Medication·Interactions·Reviewed June 9, 2026
Itraconazole interactions.
Itraconazole has 6 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Itraconazole at a glance.
A quick, data-grounded summary. The full tables are below.
Itraconazole has 6 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with itraconazole.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| St. John's Wort | Contraindicated | St. John's Wort can induce drug-metabolizing enzymes and transporters and may lower Itraconazole exposure or undermine therapy. |
| Berberine | Caution | Berberine may inhibit CYP3A4 or P-glycoprotein and could increase itraconazole intolerance in susceptible patients. |
| Green Tea Extract | Caution | Concentrated green tea extract has been associated with liver injury, which can complicate use of hepatotoxic drugs such as Itraconazole. |
| Milk Thistle | Caution | Milk thistle (silymarin) has shown weak and inconsistent effects on CYP3A4 and P-glycoprotein in laboratory studies. While clinically significant... |
| Calcium | Timing Sensitive | Calcium supplements, particularly calcium carbonate, raise gastric pH and can substantially reduce the dissolution and absorption of itraconazole... |
| Iron | Timing Sensitive | Oral iron salts are best absorbed in an acidic environment and are sometimes taken with antacids or co-administered with acid-reducing agents; more... |
The full itraconazole profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common itraconazole questions.
Quick answers drawn from the tables above.
What interacts with Itraconazole?
In the NutriStack database, Itraconazole has 6 documented interactions. The most notable include St. John's Wort, Berberine, Green Tea Extract, Milk Thistle, and Calcium. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Itraconazole?
Itraconazole is flagged against 1 substance in the database, including St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take St. John's Wort with Itraconazole?
NutriStack classifies the St. John's Wort and Itraconazole pairing as contraindicated: St. John's Wort can induce drug-metabolizing enzymes and transporters and may lower Itraconazole exposure or undermine therapy. Avoid St. John's Wort with Itraconazole. Always confirm with your prescriber.
Check your whole stack
See how itraconazole fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.