Medication·Interactions·Reviewed June 9, 2026
Lamotrigine interactions.
Lamotrigine has 5 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Lamotrigine at a glance.
A quick, data-grounded summary. The full tables are below.
Lamotrigine has 5 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with lamotrigine.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| St. John's Wort | Conflict | St. John's Wort can induce UGT glucuronidation enzymes responsible for lamotrigine metabolism, potentially reducing lamotrigine blood levels and... details → |
| Methylfolate | Caution | Lamotrigine is a weak inhibitor of dihydrofolate reductase, though clinical studies show minimal effect on serum or RBC folate in most patients.... details → |
| Valproic Acid | Caution | Valproic acid inhibits the glucuronidation of lamotrigine, approximately doubling lamotrigine levels. This increases the risk of serious skin... details → |
| Vitamin B9 | Caution | Lamotrigine is a folate antagonist that inhibits dihydrofolate reductase. Long-term use may reduce folate levels. However, folate supplementation... details → |
| Vitamin D3 | Synergy | Unlike enzyme-inducing anticonvulsants (carbamazepine, phenytoin), lamotrigine has minimal effects on CYP-mediated vitamin D catabolism and does not... details → |
The full lamotrigine profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common lamotrigine questions.
Quick answers drawn from the tables above.
What interacts with Lamotrigine?
In the NutriStack database, Lamotrigine has 5 documented interactions. The most notable include St. John's Wort, Methylfolate, Valproic Acid, Vitamin B9, and Vitamin D3. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Lamotrigine?
Lamotrigine is flagged against 1 substance in the database, including St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take St. John's Wort with Lamotrigine?
NutriStack classifies the St. John's Wort and Lamotrigine pairing as conflict: St. John's Wort can induce UGT glucuronidation enzymes responsible for lamotrigine metabolism, potentially reducing lamotrigine blood levels and risking loss of seizure... Avoid St. John's Wort while taking lamotrigine. Loss of seizure control or mood stabilization can have severe consequences including status... Always confirm with your prescriber.
Check your whole stack
See how lamotrigine fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.