Medication·Interactions·Reviewed June 9, 2026
Levomilnacipran interactions.
Levomilnacipran has 4 documented interactions in the NutriStack database, including 3 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Levomilnacipran at a glance.
A quick, data-grounded summary. The full tables are below.
Levomilnacipran has 4 documented interactions in the NutriStack database, including 3 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with levomilnacipran.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| 5-HTP | Contraindicated | 5-HTP can raise serotonin synthesis and add to levomilnacipran's serotonergic activity. |
| L-Tryptophan | Contraindicated | Supplemental L-Tryptophan increases serotonin precursor availability and may increase serotonin syndrome risk with levomilnacipran. |
| St. John's Wort | Contraindicated | St. John's Wort can increase serotonergic activity and can induce drug-metabolizing pathways. |
| Ginkgo Biloba | Caution | Levomilnacipran may increase bleeding risk, and ginkgo may add mild antiplatelet effects. |
The full levomilnacipran profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common levomilnacipran questions.
Quick answers drawn from the tables above.
What interacts with Levomilnacipran?
In the NutriStack database, Levomilnacipran has 4 documented interactions. The most notable include 5-HTP, L-Tryptophan, St. John's Wort, and Ginkgo Biloba. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Levomilnacipran?
Levomilnacipran is flagged against 3 substances in the database, including 5-HTP, L-Tryptophan, and St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take 5-HTP with Levomilnacipran?
NutriStack classifies the 5-HTP and Levomilnacipran pairing as contraindicated: 5-HTP can raise serotonin synthesis and add to levomilnacipran's serotonergic activity. Avoid 5-HTP while taking levomilnacipran. Always confirm with your prescriber.
Check your whole stack
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