Medication·Interactions·Reviewed June 9, 2026
Linezolid interactions.
Linezolid has 4 documented interactions in the NutriStack database, including 3 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Linezolid at a glance.
A quick, data-grounded summary. The full tables are below.
Linezolid has 4 documented interactions in the NutriStack database, including 3 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with linezolid.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| 5-HTP | Contraindicated | 5-HTP can increase serotonergic tone and is unsafe with Linezolid's monoamine oxidase inhibitory activity. |
| L-Tryptophan | Contraindicated | L-Tryptophan can increase serotonergic tone and is unsafe with Linezolid's monoamine oxidase inhibitory activity. |
| St. John's Wort | Contraindicated | St. John's Wort can increase serotonergic tone and is unsafe with Linezolid's monoamine oxidase inhibitory activity. |
| Vitamin B6 | Caution | Vitamin B6 (pyridoxine) is the cofactor for aromatic L-amino acid decarboxylase, the enzyme that converts 5-HTP to serotonin and L-DOPA to dopamine.... |
The full linezolid profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common linezolid questions.
Quick answers drawn from the tables above.
What interacts with Linezolid?
In the NutriStack database, Linezolid has 4 documented interactions. The most notable include 5-HTP, L-Tryptophan, St. John's Wort, and Vitamin B6. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Linezolid?
Linezolid is flagged against 3 substances in the database, including 5-HTP, L-Tryptophan, and St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take 5-HTP with Linezolid?
NutriStack classifies the 5-HTP and Linezolid pairing as contraindicated: 5-HTP can increase serotonergic tone and is unsafe with Linezolid's monoamine oxidase inhibitory activity. Avoid 5-HTP while taking Linezolid. Always confirm with your prescriber.
Check your whole stack
See how linezolid fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.