Medication·Interactions·Reviewed June 9, 2026
Lisdexamfetamine interactions.
Lisdexamfetamine has 4 documented interactions in the NutriStack database, including 2 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Lisdexamfetamine at a glance.
A quick, data-grounded summary. The full tables are below.
Lisdexamfetamine has 4 documented interactions in the NutriStack database, including 2 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with lisdexamfetamine.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Cocaine | Contraindicated | Lisdexamfetamine is converted to dextroamphetamine and produces stimulant cardiovascular effects that can overlap with cocaine. Combining them can... details → |
| MDMA | Contraindicated | Lisdexamfetamine produces dextroamphetamine exposure, and MDMA adds serotonergic and sympathomimetic stimulation. Co-use can increase risk of... details → |
| Nicotine | Caution | Nicotine and prescription psychostimulants are commonly co-used and can interact behaviorally and physiologically. With lisdexamfetamine, nicotine... |
| Vitamin C | Timing Sensitive | Lisdexamfetamine is converted to dextroamphetamine after absorption, and the active amphetamine exposure can be affected by urinary pH. High-dose... details → |
The full lisdexamfetamine profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common lisdexamfetamine questions.
Quick answers drawn from the tables above.
What interacts with Lisdexamfetamine?
In the NutriStack database, Lisdexamfetamine has 4 documented interactions. The most notable include Cocaine, MDMA, Nicotine, and Vitamin C. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Lisdexamfetamine?
Lisdexamfetamine is flagged against 2 substances in the database, including Cocaine and MDMA. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take Cocaine with Lisdexamfetamine?
NutriStack classifies the Cocaine and Lisdexamfetamine pairing as contraindicated: Lisdexamfetamine is converted to dextroamphetamine and produces stimulant cardiovascular effects that can overlap with cocaine. Combining them can increase heart rate,... Do not use cocaine while taking lisdexamfetamine. Do not raise or repeat either substance to overcome a blunted effect. Seek emergency care for... Always confirm with your prescriber.
Check your whole stack
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