Medication·Interactions·Reviewed June 9, 2026
Lithium interactions.
Lithium has 9 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Lithium at a glance.
A quick, data-grounded summary. The full tables are below.
Lithium has 9 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with lithium.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Furosemide | Caution | Loop diuretics can increase lithium levels through volume depletion, though the effect is generally less predictable than with thiazide diuretics.... details → |
| Hydrochlorothiazide | Caution | Thiazide diuretics reduce lithium clearance by 25-40%, significantly increasing the risk of lithium toxicity. This is one of the most... details → |
| Iodine | Caution | Lithium concentrates in the thyroid and inhibits thyroid hormone synthesis. Iodine supplementation in lithium-treated patients can worsen... details → |
| Lisinopril | Caution | ACE inhibitors reduce renal lithium clearance, potentially increasing lithium levels by 25-40% and causing lithium toxicity. Symptoms include... details → |
| Magnesium Glycinate | Caution | Magnesium may affect lithium excretion and distribution, as both are divalent cations handled by similar renal transport mechanisms. Changes in... |
| Potassium | Caution | Both lithium and potassium are affected by renal excretion mechanisms, and changes in potassium balance can influence lithium handling.... |
| Sertraline | Caution | While SSRIs and lithium are commonly used together in treatment-resistant depression and bipolar disorder, the combination carries a modest risk of... details → |
| Zinc | Caution | Zinc and lithium have minor interactions related to shared transport mechanisms and effects on thyroid function. While the interaction is not... |
| Fish Oil | Synergy | Fish oil (EPA/DHA) may have additive mood-stabilizing benefits when combined with lithium. Omega-3 fatty acids have demonstrated modest efficacy in... details → |
The full lithium profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common lithium questions.
Quick answers drawn from the tables above.
What interacts with Lithium?
In the NutriStack database, Lithium has 9 documented interactions. The most notable include Furosemide, Hydrochlorothiazide, Iodine, Lisinopril, and Magnesium Glycinate. Check any specific combination before taking it and confirm with your prescriber.
Is it safe to take Furosemide with Lithium?
NutriStack classifies the Furosemide and Lithium pairing as caution: Loop diuretics can increase lithium levels through volume depletion, though the effect is generally less predictable than with thiazide diuretics. Dehydration from... Monitor lithium levels closely. Ensure adequate hydration. Check lithium levels within 5-7 days of diuretic initiation or dose change. Always confirm with your prescriber.
Check your whole stack
See how lithium fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.