Medication·Interactions·Reviewed June 9, 2026
Lorazepam interactions.
Lorazepam has 5 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Lorazepam at a glance.
A quick, data-grounded summary. The full tables are below.
Lorazepam has 5 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with lorazepam.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Alcohol | Contraindicated | Alcohol compounds lorazepam's sedating, amnestic, and coordination-impairing effects. Even if lorazepam is not strongly CYP-metabolized, the... details → |
| GABA | Caution | Supplemental GABA may have sedative effects that could add to lorazepam's CNS depression. Although the extent of oral GABA's blood-brain barrier... |
| Melatonin | Caution | Melatonin's sedative effects can compound lorazepam's CNS depression. While some research suggests melatonin may help facilitate benzodiazepine... details → |
| Passionflower | Caution | Passionflower has anxiolytic and GABA-related activity that may stack with lorazepam's benzodiazepine effect. The result can be more sedation,... |
| Valerian Root | Caution | Valerian root enhances GABAergic activity, which adds to lorazepam's CNS depressant effects. This combination can lead to excessive sedation,... details → |
The full lorazepam profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common lorazepam questions.
Quick answers drawn from the tables above.
What interacts with Lorazepam?
In the NutriStack database, Lorazepam has 5 documented interactions. The most notable include Alcohol, GABA, Melatonin, Passionflower, and Valerian Root. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Lorazepam?
Lorazepam is flagged against 1 substance in the database, including Alcohol. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take Alcohol with Lorazepam?
NutriStack classifies the Alcohol and Lorazepam pairing as contraindicated: Alcohol compounds lorazepam's sedating, amnestic, and coordination-impairing effects. Even if lorazepam is not strongly CYP-metabolized, the interaction is... Avoid alcohol while taking lorazepam. If alcohol was used, do not take extra lorazepam for anxiety or sleep without medical guidance. Seek urgent... Always confirm with your prescriber.
Check your whole stack
See how lorazepam fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.