Medication·Interactions·Reviewed June 9, 2026
Lurasidone interactions.
Lurasidone has 4 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Lurasidone at a glance.
A quick, data-grounded summary. The full tables are below.
Lurasidone has 4 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with lurasidone.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| St. John's Wort | Contraindicated | St. John's Wort is a strong CYP3A4 inducer and can markedly lower lurasidone exposure. |
| Ashwagandha | Caution | Ashwagandha can cause sedation in some patients and may add to lurasidone's CNS effects. |
| L-Theanine | Caution | L-Theanine may add calming or sedating effects to lurasidone. |
| Melatonin | Caution | Melatonin can add to lurasidone-related somnolence or dizziness. |
The full lurasidone profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common lurasidone questions.
Quick answers drawn from the tables above.
What interacts with Lurasidone?
In the NutriStack database, Lurasidone has 4 documented interactions. The most notable include St. John's Wort, Ashwagandha, L-Theanine, and Melatonin. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Lurasidone?
Lurasidone is flagged against 1 substance in the database, including St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take St. John's Wort with Lurasidone?
NutriStack classifies the St. John's Wort and Lurasidone pairing as contraindicated: St. John's Wort is a strong CYP3A4 inducer and can markedly lower lurasidone exposure. Do not combine St. John's Wort with lurasidone. Always confirm with your prescriber.
Check your whole stack
See how lurasidone fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.