Medication·Interactions·Reviewed June 9, 2026
Medroxyprogesterone interactions.
Medroxyprogesterone has 5 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Medroxyprogesterone at a glance.
A quick, data-grounded summary. The full tables are below.
Medroxyprogesterone has 5 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with medroxyprogesterone.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Calcium | Synergy | Depot medroxyprogesterone acetate (DMPA) is associated with a measurable but largely reversible decrease in bone mineral density during use.... details → |
| Magnesium Glycinate | Synergy | Magnesium plays a structural and signaling role in bone health and supports the calcium-vitamin D-PTH axis. Although direct DMPA trials are limited,... |
| Vitamin B6 | Synergy | DMPA can cause or worsen low mood in some users, and depleted B6 status (common in women on hormonal contraception) may contribute. Modest B6... details → |
| Vitamin D3 | Synergy | Vitamin D adequacy is essential for the bone-protective effect of calcium during DMPA use. Without adequate vitamin D, dietary calcium cannot be... details → |
| Vitamin K2 | Synergy | Vitamin K2 complements calcium and vitamin D for bone protection during DMPA use by activating osteocalcin and matrix Gla protein. Although direct... |
The full medroxyprogesterone profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common medroxyprogesterone questions.
Quick answers drawn from the tables above.
What interacts with Medroxyprogesterone?
In the NutriStack database, Medroxyprogesterone has 5 documented interactions. The most notable include Calcium, Magnesium Glycinate, Vitamin B6, Vitamin D3, and Vitamin K2. Check any specific combination before taking it and confirm with your prescriber.
Is it safe to take Calcium with Medroxyprogesterone?
NutriStack classifies the Calcium and Medroxyprogesterone pairing as synergy: Depot medroxyprogesterone acetate (DMPA) is associated with a measurable but largely reversible decrease in bone mineral density during use. Adequate calcium intake... Aim for 1000-1300 mg/day total calcium from diet plus supplements while on DMPA. Split supplemental doses (500 mg or less per serving) for best... Always confirm with your prescriber.
Check your whole stack
See how medroxyprogesterone fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.