Medication·Interactions·Reviewed June 9, 2026
Methimazole interactions.
Methimazole has 4 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Methimazole at a glance.
A quick, data-grounded summary. The full tables are below.
Methimazole has 4 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with methimazole.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Ashwagandha | Conflict | Ashwagandha may increase thyroid hormone levels or trigger thyrotoxicosis in susceptible people. That can oppose the purpose of methimazole, which... |
| Iodine | Caution | Iodine intake can change how Graves' disease responds to methimazole. High or unstable iodine exposure can alter thyroid hormone synthesis and may... details → |
| Vitamin B7 | Caution | Vitamin B7 can interfere with thyroid immunoassays used to monitor methimazole treatment. The pattern can mimic Graves' disease activity by making... details → |
| Selenium | Synergy | Selenium has been studied as an add-on to methimazole in Graves' disease. Some smaller trials suggest improved antibody or early biochemical... details → |
The full methimazole profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common methimazole questions.
Quick answers drawn from the tables above.
What interacts with Methimazole?
In the NutriStack database, Methimazole has 4 documented interactions. The most notable include Ashwagandha, Iodine, Vitamin B7, and Selenium. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Methimazole?
Methimazole is flagged against 1 substance in the database, including Ashwagandha. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take Ashwagandha with Methimazole?
NutriStack classifies the Ashwagandha and Methimazole pairing as conflict: Ashwagandha may increase thyroid hormone levels or trigger thyrotoxicosis in susceptible people. That can oppose the purpose of methimazole, which is used to bring... Avoid ashwagandha while taking methimazole unless your thyroid clinician explicitly approves it. If you have already started it, report... Always confirm with your prescriber.
Check your whole stack
See how methimazole fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.