Medication·Interactions·Reviewed June 9, 2026
Naproxen interactions.
Naproxen has 8 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Naproxen at a glance.
A quick, data-grounded summary. The full tables are below.
Naproxen has 8 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with naproxen.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Alcohol | Caution | Alcohol can compound naproxen's gastrointestinal bleeding risk. Naproxen is among the NSAIDs more strongly associated with upper GI complications,... details → |
| Fish Oil | Caution | Naproxen has stronger antiplatelet effects than most NSAIDs. Combined with fish oil's antiplatelet properties, there is additive bleeding risk. details → |
| Garlic Extract | Caution | Concentrated garlic extract may add antiplatelet effects to naproxen's GI bleeding risk. Naproxen has a relatively strong association with upper GI... |
| Ginkgo Biloba | Caution | Ginkgo biloba may increase bleeding risk when combined with naproxen. Ginkgo has case reports of spontaneous bleeding, while naproxen is a... |
| Methotrexate | Caution | Naproxen, like other NSAIDs, reduces renal clearance of methotrexate. The longer half-life of naproxen may pose even greater accumulation risk... details → |
| Nattokinase | Caution | Nattokinase may add fibrinolytic and anticoagulant effects to naproxen's GI bleeding risk. Naproxen is a higher-GI-risk NSAID, so a supplement that... |
| Potassium | Caution | Naproxen can impair kidney potassium handling, and potassium supplements can add enough potassium to cause hyperkalemia in susceptible people. Risk... details → |
| Turmeric/Curcumin | Caution | Concentrated turmeric/curcumin may add antiplatelet activity to naproxen's GI bleeding risk. Naproxen has a relatively strong association with upper... |
The full naproxen profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common naproxen questions.
Quick answers drawn from the tables above.
What interacts with Naproxen?
In the NutriStack database, Naproxen has 8 documented interactions. The most notable include Alcohol, Fish Oil, Garlic Extract, Ginkgo Biloba, and Methotrexate. Check any specific combination before taking it and confirm with your prescriber.
Is it safe to take Alcohol with Naproxen?
NutriStack classifies the Alcohol and Naproxen pairing as caution: Alcohol can compound naproxen's gastrointestinal bleeding risk. Naproxen is among the NSAIDs more strongly associated with upper GI complications, and alcohol adds... Avoid heavy alcohol use while taking naproxen. If you need regular naproxen, discuss stomach-protection options and seek urgent care for black... Always confirm with your prescriber.
Check your whole stack
See how naproxen fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.