Medication·Interactions·Reviewed June 9, 2026
Nifedipine interactions.
Nifedipine has 5 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Nifedipine at a glance.
A quick, data-grounded summary. The full tables are below.
Nifedipine has 5 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with nifedipine.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| St. John's Wort | Conflict | St. John's Wort induces CYP3A4, which is the primary metabolic pathway for nifedipine. This can dramatically reduce nifedipine levels and blood... details → |
| Berberine | Caution | Nifedipine relies on CYP3A4 for clearance, and berberine clinically inhibits CYP3A4 after repeated dosing in humans. Co-administration can raise... details → |
| Garlic Extract | Caution | Aged garlic extract lowers systolic and diastolic blood pressure by about 8 and 5 mmHg in hypertensive patients. Stacked on top of nifedipine's... details → |
| Magnesium Citrate | Caution | Magnesium is a physiologic calcium-channel modulator that lowers blood pressure by about 2 mmHg systolic at supplemental doses. Combined with... details → |
| Resveratrol | Caution | Resveratrol inhibits CYP3A4 and intestinal P-glycoprotein, and in rats it raised nicardipine AUC 111-126% via both mechanisms. Because nifedipine... |
The full nifedipine profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common nifedipine questions.
Quick answers drawn from the tables above.
What interacts with Nifedipine?
In the NutriStack database, Nifedipine has 5 documented interactions. The most notable include St. John's Wort, Berberine, Garlic Extract, Magnesium Citrate, and Resveratrol. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Nifedipine?
Nifedipine is flagged against 1 substance in the database, including St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take St. John's Wort with Nifedipine?
NutriStack classifies the St. John's Wort and Nifedipine pairing as conflict: St. John's Wort induces CYP3A4, which is the primary metabolic pathway for nifedipine. This can dramatically reduce nifedipine levels and blood pressure control. Avoid St. John's Wort with nifedipine. A documented case showed a patient's BP rose from controlled to 180/100 after starting SJW. Always confirm with your prescriber.
Check your whole stack
See how nifedipine fits your supplements.
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