Medication·Interactions·Reviewed June 9, 2026
Oxycodone interactions.
Oxycodone has 4 documented interactions in the NutriStack database, including 2 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Oxycodone at a glance.
A quick, data-grounded summary. The full tables are below.
Oxycodone has 4 documented interactions in the NutriStack database, including 2 flagged to avoid or as a serious conflict. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with oxycodone.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Alcohol | Contraindicated | Alcohol substantially increases the respiratory depression caused by oxycodone. In a controlled human study, oxycodone reduced ventilation and... details → |
| Alprazolam | Contraindicated | FDA Black Box Warning: Concurrent use of opioids and benzodiazepines can result in profound sedation, respiratory depression, coma, and death. This... details → |
| Cannabis (THC-Dominant) | Caution | Controlled human studies show that THC-dominant cannabis can interact meaningfully with oxycodone. One respiratory study found oxycodone reduced... details → |
| St. John's Wort | Caution | St. John's Wort can induce CYP3A activity, and oxycodone exposure is clinically sensitive to CYP3A induction and inhibition. Using them together may... details → |
The full oxycodone profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common oxycodone questions.
Quick answers drawn from the tables above.
What interacts with Oxycodone?
In the NutriStack database, Oxycodone has 4 documented interactions. The most notable include Alcohol, Alprazolam, Cannabis (THC-Dominant), and St. John's Wort. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Oxycodone?
Oxycodone is flagged against 2 substances in the database, including Alcohol and Alprazolam. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Is it safe to take Alcohol with Oxycodone?
NutriStack classifies the Alcohol and Oxycodone pairing as contraindicated: Alcohol substantially increases the respiratory depression caused by oxycodone. In a controlled human study, oxycodone reduced ventilation and alcohol caused a further... Do not drink alcohol while taking oxycodone. Avoid driving, sleeping alone after accidental co-use, or taking any extra sedatives. Call emergency... Always confirm with your prescriber.
Check your whole stack
See how oxycodone fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.