Medication·Interactions·Reviewed June 9, 2026
Pioglitazone interactions.
Pioglitazone has 4 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Pioglitazone at a glance.
A quick, data-grounded summary. The full tables are below.
Pioglitazone has 4 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with pioglitazone.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Alpha-Lipoic Acid | Caution | Alpha-Lipoic Acid may lower glucose and add to the glucose-lowering effects of Pioglitazone. |
| Berberine | Caution | Berberine may lower glucose and add to the glucose-lowering effects of Pioglitazone. |
| St. John's Wort | Caution | St. John's Wort can induce drug-metabolizing enzymes and transporters and may lower Pioglitazone exposure or undermine therapy. |
| Vitamin D3 | Synergy | Pioglitazone increases fracture risk; correcting vitamin D deficiency is relevant to bone-health risk reduction. |
The full pioglitazone profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common pioglitazone questions.
Quick answers drawn from the tables above.
What interacts with Pioglitazone?
In the NutriStack database, Pioglitazone has 4 documented interactions. The most notable include Alpha-Lipoic Acid, Berberine, St. John's Wort, and Vitamin D3. Check any specific combination before taking it and confirm with your prescriber.
Is it safe to take Alpha-Lipoic Acid with Pioglitazone?
NutriStack classifies the Alpha-Lipoic Acid and Pioglitazone pairing as caution: Alpha-Lipoic Acid may lower glucose and add to the glucose-lowering effects of Pioglitazone. Increase glucose monitoring when starting, stopping, or changing the supplement; coordinate diabetes medication adjustments with the prescriber. Always confirm with your prescriber.
Check your whole stack
See how pioglitazone fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.