Medication·Interactions·Reviewed June 9, 2026
Promethazine interactions.
Promethazine has 3 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Promethazine at a glance.
A quick, data-grounded summary. The full tables are below.
Promethazine has 3 documented interactions in the NutriStack database. The full interaction list is below. None of this is a substitute for your prescriber's advice.
Substances that interact with promethazine.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Alcohol | Caution | Alcohol can add to promethazine's sedating, anticholinergic, and coordination-impairing effects. Human studies show promethazine impairs psychomotor... details → |
| Cannabis (THC-Dominant) | Caution | THC-dominant cannabis can add to promethazine-related sedation, slowed reactions, and impaired coordination. Promethazine impairs psychomotor... details → |
| Melatonin | Caution | Melatonin can add to promethazine-related drowsiness, slowed reaction time, and next-day grogginess. Promethazine significantly impairs psychomotor... |
The full promethazine profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common promethazine questions.
Quick answers drawn from the tables above.
What interacts with Promethazine?
In the NutriStack database, Promethazine has 3 documented interactions. The most notable include Alcohol, Cannabis (THC-Dominant), and Melatonin. Check any specific combination before taking it and confirm with your prescriber.
Is it safe to take Alcohol with Promethazine?
NutriStack classifies the Alcohol and Promethazine pairing as caution: Alcohol can add to promethazine's sedating, anticholinergic, and coordination-impairing effects. Human studies show promethazine impairs psychomotor performance, and... Avoid alcohol while taking promethazine for nausea, allergy, cough, or sleep. Do not drive or combine it with other sedatives if alcohol was used.... Always confirm with your prescriber.
Check your whole stack
See how promethazine fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.